Langenbeck's Archives of Surgery

, Volume 399, Issue 4, pp 415–420 | Cite as

HLA antibody screening in kidney transplantation: current guidelines

Review Article

Abstract

Background

In organ transplantation, the introduction of the solid phase immunoassay technology radically changed the practice of antibody monitoring against human leukocyte antigens (HLA).

Purpose

Precise identification of antibody specificities in complex sera of sensitized patients and monitoring of low levels of donor-specific HLA antibodies in the posttransplant phase became possible. However, at the same time, new technical problems and great variation emerged in the interpretation of test results, indicating a need for standardization.

Conclusion

In May 2012, The Transplantation Society (TTS) recruited a panel of laboratory and clinical experts to discuss emerging testing and clinical management issues that are associated with antibody testing in organ transplantation. In this article, we provide a summary of the TTS recommendations formulated in this international effort on the standardization of antibody monitoring in kidney transplantation.

Keywords

Single antigen bead HLA antibodies Kidney transplantation Consensus guidelines 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Dániel Wettstein
    • 1
  • Gerhard Opelz
    • 1
  • Caner Süsal
    • 1
  1. 1.Department of Transplantation Immunology, Institute of ImmunologyUniversity of HeidelbergHeidelbergGermany

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