Real-time ultrasound elastography—a noninvasive diagnostic procedure for evaluating dominant thyroid nodules
- 504 Downloads
Ultrasound elastography (USE) is a newly developed technique for the evaluation of tissue stiffness. It is known that malignancies often show a low-strain value. So far, only limited data for thyroid nodules is available.
This study included 309 prospective evaluated patients with dominant, nontoxic thyroid nodules. All patients were referred to surgery. USE was performed preoperatively. Three measuring groups were formed: hard (< 0.15), intermediate (0.16–0.3), and soft (> 0.31). The measurements were correlated to the final histological findings.
The strain rated from 0.01 to 0.84 (mean 0.26 ± 0.13). A total of 50 thyroid malignancies (35 papillara carcinoma, 9 medullary carcinoma, and 6 follicular carcinoma) were observed. Patients (81) were within the hard group, 35 of them (43.2%) had thyroid cancer (TC) in final histology. Out of 132 patients in the intermediate group, 15 patients had TC (11.4%). All 96 patients from the soft group showed benign histological results (NPV 100%). Seventy percent of patients with TC were within the hard group (PPV 42%). These results were highly significant (p < 0.001). Coarse calcifications and cystic nodules were not connected with reliable measurements and therefore are not suitable for USE.
USE is a useful adjunctive tool in the workup of thyroid nodules. A low strain value needs surgical intervention, whereas a high strain value predicts a benign histology. It might substitute fine-needle aspiration cytology in the future.
KeywordsThyroid nodules Elastography Thyroid ultrasound Thyroid surgery Thyroid cancer
- 6.Frates MC, Benson CB, Charboneau JW, Cibas ES, Clark OH, Coleman BG, et al (2006) Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Ultrasound Q 22(4):231–8; discussion 239–40.Google Scholar
- 13.Thomas A, Degenhardt F, Farrokh A, Wojcinski S, Slowinski T, Fischer T (2010) Significant differentiation of focal breast lesions calculation of strain ratio in breast sonoelastography. Acad Radiol 18Google Scholar
- 17.Yang J, Schnadig V, Logrono R, Wasserman PG (2007) Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer 25;111(5):306–15Google Scholar