Langenbeck's Archives of Surgery

, Volume 395, Issue 2, pp 127–132 | Cite as

The false-negative rate of fine-needle aspiration cytology for diagnosing thyroid carcinoma in thyroid nodules

  • Bekir Kuru
  • Nese Ersoz Gulcelik
  • Mehmet Ali Gulcelik
  • Halil Dincer
Original Article



Our aim was to define the false-negative rate of fine-needle aspiration cytology (FNAC) for diagnosing thyroid carcinoma in thyroid nodules <4 cm versus ≥4 cm.

Materials and methods

Six hundred sixty-two patients with thyroid nodules who underwent FNAC and surgery at our institution were analyzed. The association of predictive factors with thyroid carcinoma was evaluated. The sensitivity, specificity, and the false-negative rate of FNAC were calculated.


The incidence of thyroid carcinoma was significantly higher in nodules ≥4 cm (24%) compared with nodules <4 cm (12%). The false-negative rates of FNAC were 2% in all nodules and 1.3% and 4.3% in nodules <4 cm and ≥4 cm (p = 0.9), respectively. Sensitivity and specificity of FNAC were 90% and 79%, respectively.


The false-negative rate of FNAC is low for thyroid nodules <4 cm and for nodules ≥4 cm.


Thyroid nodules Thyroid carcinoma Fine-needle aspiration biopsy False-negative rates of fine-needle aspiration biopsy in thyroid nodules <4 cm and ≥4 cm 


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Bekir Kuru
    • 1
    • 7
  • Nese Ersoz Gulcelik
    • 2
    • 3
  • Mehmet Ali Gulcelik
    • 4
    • 5
  • Halil Dincer
    • 4
    • 6
  1. 1.Department of General SurgeryOndokuz Mayis University School of MedicineSamsunTurkey
  2. 2.Department of EndocrinologyHacettepe University School of MedicineAnkaraTurkey
  3. 3.AnkaraTurkey
  4. 4.Department of General SurgeryAnkara Oncology Education and Research HospitalAnkaraTurkey
  5. 5.AnkaraTurkey
  6. 6.AnkaraTurkey
  7. 7.SamsunTurkey

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