New randomized trial of probiotics in pancreatitis needed? Caution advised
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We support the use of large-scale, high-quality, placebo-controlled randomized trials as much as Dr. Sun and co-workers do . However, we do not support their rather strong conclusion that a new randomized trial of probiotic prophylaxis in patients with predicted severe acute pancreatitis is currently warranted.
In their meta-analysis, Sun et al. detected no significant effects of probiotic prophylaxis in patients with acute pancreatitis . In our double-blind study on the effect of combined probiotic strains, which had a sample size almost five times larger than the previous studies, we detected a significant increase in both mortality and bowel ischemia . These were all well-reputed probiotic strains that had been used for a long time without any negative effects being reported. The major difference between our study and the previous three studies is the much larger number of patients with concurrent organ failure. In their studies, Olah et al. included only four...
KeywordsPancreatitis Acute Pancreatitis Organ Failure Systemic Inflammatory Response Syndrome Severe Acute Pancreatitis
- 1.Sun S, Yang K, He X, Tian J, Ma B, Jiang L (2008) Probiotics in patients with severe acute pancreatitis: a meta-analysis. Langenbecks Arch Surg. doi: 10.1007/s00423-008-0379-2