Metastases to the thyroid gland: seventeen cases operated on in a single clinical center

  • Stanisław Cichoń
  • Ryszard Anielski
  • Aleksander KonturekEmail author
  • Marcin Barczyński
  • Wojciech Cichoń
Original Article


Background and aims

In spite of its rich vasculature, the thyroid gland is rarely the site of metastatic disease. The incidence of such metastases differs depending on the type of the analyzed material. In clinical papers, the incidence is low and, according to various sources, amounts to 2–3% of all malignant tumors of the thyroid. Most commonly, the primary tumor is located in the breast, bronchi, gastrointestinal system, (the colon, esophagus, or stomach) and kidneys. Usually, metastatic thyroid disease is identified upon autopsy, and only sporadic cases are encountered in clinical material. The authors present their experience in treating metastatic disease involving the thyroid gland based on the analysis of their clinical material consisting of patients operated on in a single center.

Materials and methods

Seventeen patients presented with metastatic tumors of the thyroid. The material was further analyzed retrospectively. The group included four men and 13 women, with the male to female ratio of 1:4.25. The age of the patients ranged from 46 to 76 years, with the mean age amounting to 62±9.78 years. Eleven patients were diagnosed based on fine needle aspiration biopsy (FNAB).


In 13 patients, the primary lesion was a clear cell carcinoma of the kidney, in one breast cancer, in another one uterine carcinoma. In two patients, no primary focus location was established. All the patients were treated surgically. Twelve patients were consistently followed up after the surgery. Of this group, seven are still alive, including five individuals with metastases of renal carcinomas, but without recurrent disease. Five patients died due to disseminated neoplastic disease. No data are available on three patients. The mean follow-up time after thyroid surgery was 3.9 years. The longest followed-up survival time was 11 years.


The most commonly clinically detected and treated surgically metastatic lesion of the thyroid gland is clear cell cancer of the kidney. In cases of renal cancer metastases to the thyroid gland, a total thyroidectomy seems to be warranted, although it does not affect the survival time.


Thyroid cancer Thyroid metastases Clear cell cancer 


  1. 1.
    Barczynski M, Jamski J, Cichon S, Barczynski M, Sulowicz W (2000) Diagnosis, treatment and prognosis in cases of renal clear cell carcinoma metastases into the thyroid gland. Przegl Lek 57(3):157–159PubMedGoogle Scholar
  2. 2.
    Bayram F, Soyuer I, Atmaca H, Demirci D, Gokce C, Canoz O, Unluhizarci K, Kelestimur F (2004) Prostatic adenocarcinoma metastasis in the thyroid gland. Endocr J 51(4):445–448PubMedCrossRefGoogle Scholar
  3. 3.
    Boggess MA, Hester TO, Archer SM (1996) Renal clear cell carcinoma appearing as a left neck mass. Ear Nose Throat J 75:620–622PubMedGoogle Scholar
  4. 4.
    Berge T, Lundberg S (1977) Cancer in Malmo 1958–1969. An autopsy study. Acta Pathol Microbiol Scand Suppl 260:1–235PubMedGoogle Scholar
  5. 5.
    Chen H, Nicol TL, Udelsman R (1999) Clinically significant, isolated metastatic disease to the thyroid gland. World J Surg 23(2):177–181PubMedCrossRefGoogle Scholar
  6. 6.
    Chung SY, Kim EK, Kim JH, Oh KK, Kim DJ, Lee YH, An HJ, Kim JS (2001) Sonographic findings of metastatic disease to the thyroid. Yonsei Med J 42(4):411–417PubMedGoogle Scholar
  7. 7.
    Congui A, Nicolosi A, Malloci A et al (1994) Metastasi tiroidea e cutanea isolate de carcinoma renale. Minerva Chir 49:223Google Scholar
  8. 8.
    Croce A, Moretti A, Bianchedi M (1991) Thyroid gland involvement in cancer of the larynx. Acta Otorhinolaryngol Ital 11(4):429–435PubMedGoogle Scholar
  9. 9.
    De Groot LJ, Larsen PR, Hennemann G (1996) Thyroid neoplasia. In: De Groot LJ, Larsen PR, Hennemann G (eds) The thyroid and its diseases, 6th edn. Churchill Livingstone, New York, pp 635–696Google Scholar
  10. 10.
    Dequanter D, Lothaire P, Larsimont D, de Saint-Aubain de Somerhausen N, Andry G (2004) Intrathyroid metastasis: 11 cases. Ann Endocrinol (Paris) 65(3):205–208Google Scholar
  11. 11.
    De Ridder M, Sermeus AB, Urbain D, Storme GA (2003) Metastases to the thyroid gland—a report of six cases. Eur J Intern Med 14(6):377–379PubMedCrossRefGoogle Scholar
  12. 12.
    Giuffrida D, Ferrau F, Pappalardo A, Aiello RA, Bordonaro R, Cordio S, Giorgio CG, Squatrito S (2003) Metastasis to the thyroid gland: a case report and review of the literature. J Endocrinol Invest 26(6):560–563PubMedGoogle Scholar
  13. 13.
    Hadjadj S, Geoffrois L, Aubert V, Weryha G, Leclere J (1995) Thyroid metastases from cancer of the kidney. Two cases. Presse Med 24(30):1386–1388PubMedGoogle Scholar
  14. 14.
    Haugen BR, Nawaz S, Cohn A, Shroyer K, Bunn PA Jr, Liechty DR, Ridgway EC (1994) Secondary malignancy of the thyroid gland: a case report and review of the literature. Thyroid 4(3):297–300PubMedCrossRefGoogle Scholar
  15. 15.
    Heffess CS, Wenig BM, Thompson LD (2002) Metastatic renal cell carcinoma to the thyroid gland: a clinicopathologic study of 36 cases. Cancer 95(9):1869–1878PubMedCrossRefGoogle Scholar
  16. 16.
    Hellsten S, Berge T, Linell F (1983) Clinically unrecognised renal carcinoma: aspects of tumor morphology, lymphatic and haematogenous metastatic spread. Br J Urol 55(2):166–170PubMedCrossRefGoogle Scholar
  17. 17.
    Kierney PC, van Heerden JA, Segura JW, Weaver AL (1994) Surgeon’s role in the management of solitary renal cell carcinoma metastases occurring subsequent to initial curative nephrectomy: an institutional review. Ann Surg Oncol 1(4):345–352PubMedCrossRefGoogle Scholar
  18. 18.
    Lam KY, Lo CY (1998) Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients. Arch Pathol Lab Med 122(1):37–41PubMedGoogle Scholar
  19. 19.
    Lin JD, Weng HF, Ho YS (1998) Clinical and pathological characteristics of secondary thyroid cancer. Thyroid 8(2):149–153PubMedCrossRefGoogle Scholar
  20. 20.
    May M, Marusch F, Kaufmann O, Seehafer M, Helke C, Hoschke B, Gastinger I (2003) Solitary renal cell carcinoma metastasis to the thyroid gland—a paradigm of metastasectomy? Chirurg 74(8):768–774PubMedCrossRefGoogle Scholar
  21. 21.
    Nakhjavani MK, Gharib H, Goellner JR, van Heerden JA (1997) Metastasis to the thyroid gland. A report of 43 cases. Cancer 79(3):574–578PubMedCrossRefGoogle Scholar
  22. 22.
    Poon D, Toh HC, Sim CS (2004) Two case reports of metastases from colon carcinoma to the thyroid. Ann Acad Med Singapore 33(1):100–102PubMedGoogle Scholar
  23. 23.
    Schroder S, Burk CG, de Heer K (1987) Metastases of the thyroid gland-morphology and clinical aspects of 25 secondary thyroid neoplasms. Langenbecks Arch Chir 370(1):25–35PubMedCrossRefGoogle Scholar
  24. 24.
    Sugimura H, Tamura S, Kodama T, Kakitsubata Y, Asada K, Watanabe K (1991) Metastatic pancreas cancer from the thyroid; clinical imaging mimicking non functioning islet cell tumor. Radiat Med 9(5):167–169PubMedGoogle Scholar
  25. 25.
    Takashima S, Takayama F, Wang JC, Saito A, Kawakami S, Kobayashi S, Sone S (2000) Radiologic assessment of metastases to the thyroid gland. J Comput Assist Tomogr 24(4):539–545PubMedCrossRefGoogle Scholar
  26. 26.
    Wartofsky L (1998) Diseases of thyroid. In: Fauci AS, Braunwald E, Isselbacher K, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL (eds) Principles of internal medicine, 14th edn. McGraw-Hill, New York, pp 2012–2035Google Scholar
  27. 27.
    Wood K, Vini L, Harmer C (2004) Metastases to the thyroid gland: the Royal Marsden experience. Eur J Surg Oncol 30(6):583–588PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Stanisław Cichoń
    • 1
  • Ryszard Anielski
    • 1
  • Aleksander Konturek
    • 1
    • 2
    Email author
  • Marcin Barczyński
    • 1
  • Wojciech Cichoń
    • 1
  1. 1.3rd Chair of General Surgery, Department of Endocrine SurgeryJagiellonian University College of MedicineKrakówPoland
  2. 2.KrakówPoland

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