Biological Cybernetics

, Volume 81, Issue 4, pp 359–371 | Cite as

Oscillatory models of the hippocampus: A study of spatio-temporal patterns of neural activity

  • Roman Borisyuk
  • Frank Hoppensteadt


Spatial patterns of theta-rhythm activity in oscillatory models of the hippocampus are studied here using canonical models for both Hodgkin's class-1 and class-2 excitable neuronal systems. Dynamics of these models are studied in both the frequency domain, to determine phase-locking patterns, and in the time domain, to determine the amplitude responses resulting from phase-locking patterns. Computer simulations presented here demonstrate that phase deviations (timings) between inputs from the medial septum and the entorhinal cortex can create spatial patterns of theta-rhythm phase-locking. In this way, we show that the timing of inputs (not only their frequencies alone) can encode specific patterns of theta-rhythm activity. This study suggests new experiments to determine temporal and spatial synchronization.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Roman Borisyuk
    • 1
  • Frank Hoppensteadt
    • 2
  1. 1. Centre for Neural and Adaptive Systems, School of Computing, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UKGB
  2. 2. Center for Systems Science, Arizona State University, Tempe, AZ 85287-7606, USAUS

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