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Biological Cybernetics

, Volume 81, Issue 4, pp 359–371 | Cite as

Oscillatory models of the hippocampus: A study of spatio-temporal patterns of neural activity

  • Roman Borisyuk
  • Frank Hoppensteadt
Article

Abstract.

Spatial patterns of theta-rhythm activity in oscillatory models of the hippocampus are studied here using canonical models for both Hodgkin's class-1 and class-2 excitable neuronal systems. Dynamics of these models are studied in both the frequency domain, to determine phase-locking patterns, and in the time domain, to determine the amplitude responses resulting from phase-locking patterns. Computer simulations presented here demonstrate that phase deviations (timings) between inputs from the medial septum and the entorhinal cortex can create spatial patterns of theta-rhythm phase-locking. In this way, we show that the timing of inputs (not only their frequencies alone) can encode specific patterns of theta-rhythm activity. This study suggests new experiments to determine temporal and spatial synchronization.

Keywords

Computer Simulation Spatial Pattern Frequency Domain Phase Deviation Neural Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Roman Borisyuk
    • 1
  • Frank Hoppensteadt
    • 2
  1. 1. Centre for Neural and Adaptive Systems, School of Computing, University of Plymouth, Drake Circus, Plymouth, PL4 8AA, UKGB
  2. 2. Center for Systems Science, Arizona State University, Tempe, AZ 85287-7606, USAUS

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