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Biological Cybernetics

, Volume 80, Issue 5, pp 291–297 | Cite as

Coefficient of variation of interspike intervals greater than 0.5. How and when?

  • Jianfeng Feng
  • David Brown
Article

Abstract.

Using Stein's model with and without reversal potentials, we investigated the mechanism of production of spike trains with a CV (ISI) (standard deviation/mean interspike interval) greater than 0.5, as observed in the visual cortex. When the attractor of the deterministic part of the dynamics is below the firing threshold, spike generation results primarily from random fluctuations. Using computer simulation for a range of membrane decay times and with other model parameters set to values appropriate for the visual cortex, we demonstrate that CV (ISI) is then usually greater than 0.5; if the attractor is above the threshold, spike generation is mainly due to deterministic forces, and CV (ISI) is then usually lower than 0.5. The critical value of the inhibitory postsynaptic potential (IPSP) rate at which CV (ISI) becomes greater than 0.5 is determined, resulting in specifications of how neurones might adjust their synaptic inputs to elicit irregular spike trains.

Keywords

Computer Simulation Stein Generation Result Visual Cortex Decay Time 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • Jianfeng Feng
    • 1
  • David Brown
    • 1
  1. 1.Computational Neuroscience Laboratory, The Babraham Institute, Cambridge CB2 4AT, UKGB

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