Biological Cybernetics

, Volume 83, Issue 2, pp 85–92 | Cite as

Effect of imbalance in activities between ON- and OFF-center LGN cells on orientation map formation

  • Hayato Nakagama
  • Tomoya Saito
  • Shigeru Tanaka


 It has been reported that the OFF responses of cells in the visual pathway are stronger, on average, than the ON responses early in the life of cats and ferrets. In this study, we theoretically investigate the effects of this imbalance in activity on the orientation map formation. We carry out computer simulations based on our previously proposed self-organization model, in which the correlated activities between ON- and OFF-center cells in the lateral geniculate nucleus regulate the formation of orientation maps in the visual cortex. When imbalance between the activities of these ON- and OFF-center cells is assumed, we obtain orientation maps with spatial periodicity, as observed in the experiments. On the other hand, when balanced activities are assumed, orientation maps do not show periodicity. This suggests that the imbalance in activities between ON- and OFF-center cells contributes to the elaboration of orientation maps during the critical period.


Computer Simulation Visual Cortex Critical Period Lateral Geniculate Nucleus Visual Pathway 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Hayato Nakagama
    • 1
  • Tomoya Saito
    • 3
  • Shigeru Tanaka
    • 2
  1. 1. Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-0041, JapanJP
  2. 2. Laboratory for Neural Modeling, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanJP
  3. 3. NEC Informatec Systems, Ltd., 3-2-1 Sakato, Takatsu, Kawasaki, Kanagawa 213-0012, JapanJP

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