Biological Cybernetics

, Volume 106, Issue 1, pp 27–36 | Cite as

Unlearning tinnitus-related cerebral synchrony with acoustic coordinated reset stimulation: theoretical concept and modelling

Open Access
Original Paper


Tinnitus is a deafferentation-induced phantom phenomenon characterized by abnormal cerebral synchrony and connectivity. Computationally, we show that desynchronizing acoustic coordinated reset (CR) stimulation can effectively counteract both up-regulated synchrony and connectivity. CR stimulation has initially been developed for the application to electrical deep brain stimulation. We here adapt this approach to non-invasive, acoustic CR stimulation. For this, we use the tonotopic organization of the central auditory system and replace electrical stimulation bursts applied to different brain sites by acoustically delivered tones of different pitch. Based on our simulations, we propose non-invasive acoustic CR stimulation as a possible novel therapy for tinnitus.


Tinnitus Coordinated reset Anti-kindling Spike timing-dependent plasticity Multistability 


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Copyright information

© The Author(s) 2012

Authors and Affiliations

  1. 1.Institute of Neuroscience and Medicine - Neuromodulation (INM-7), Research Center JülichJülichGermany
  2. 2.Department of Stereotaxic and Functional NeurosurgeryUniversity HospitalCologneGermany

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