Biological Cybernetics

, 103:43

Intrinsic variability of latency to first-spike

  • Wainrib Gilles
  • Thieullen Michèle
  • Pakdaman Khashayar
Original Paper

Abstract

The assessment of the variability of neuronal spike timing is fundamental to gain understanding of latency coding. Based on recent mathematical results, we investigate theoretically the impact of channel noise on latency variability. For large numbers of ion channels, we derive the asymptotic distribution of latency, together with an explicit expression for its variance. Consequences in terms of information processing are studied with Fisher information in the Morris–Lecar model. A competition between sensitivity to input and precision is responsible for favoring two distinct regimes of latencies.

Keywords

Latency coding Channel noise Fisher information Morris–Lecar model 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Wainrib Gilles
    • 1
  • Thieullen Michèle
    • 2
  • Pakdaman Khashayar
    • 3
  1. 1.Centre de Recherche en Epistémologie Appliquée, UMR 7656, Ecole Polytechnique, CNRSParisFrance
  2. 2.Laboratoire de Probabilités et Modèles Aléatoires (LPMA), UMR 7599, CNRSParisFrance
  3. 3.Institut Jacques Monod (IJM), UMR 7592, CNRSParisFrance

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