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Biological Cybernetics

, Volume 95, Issue 4, pp 289–310 | Cite as

Modeling the contribution of lamina 5 neuronal and network dynamics to low frequency EEG phenomena

  • Fadi N. KaramehEmail author
  • Munther A. Dahleh
  • Emery N. Brown
  • Steve G. Massaquoi
Original Paper

Abstract

The Electroencephalogram (EEG) is an important clinical and research tool in neurophysiology. With the advent of recording techniques, new evidence is emerging on the neuronal populations and wiring in the neocortex. A main challenge is to relate the EEG generation mechanisms to the underlying circuitry of the neocortex. In this paper, we look at the principal intrinsic properties of neocortical cells in layer 5 and their network behavior in simplified simulation models to explain the emergence of several important EEG phenomena such as the alpha rhythms, slow-wave sleep oscillations, and a form of cortical seizure. The models also predict the ability of layer 5 cells to produce a resonance-like neuronal recruitment known as the augmenting response. While previous models point to deeper brain structures, such as the thalamus, as the origin of many EEG rhythms (spindles), the current model suggests that the cortical circuitry itself has intrinsic oscillatory dynamics which could account for a wide variety of EEG phenomena.

Keywords

Pyramidal Cell Alpha Rhythm Cereb Cortex Cortical Column Supplementary Material Section 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Supplementary material

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Supplementary material

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Fadi N. Karameh
    • 1
    Email author
  • Munther A. Dahleh
    • 2
  • Emery N. Brown
    • 3
    • 4
  • Steve G. Massaquoi
    • 2
    • 5
  1. 1.Department of Electrical and Computer EngineeringAmerican University of BeirutBeirutLebanon
  2. 2.Department of Electrical Engineering and Computer ScienceMassachusetts Institute of TechnologyCambridgeUSA
  3. 3.Department of Brain and Cognitive Sciences, MIT-Harvard Division of Health Science and TechnologyMassachusetts Institute of TechnologyCambridgeUSA
  4. 4.Neuroscience Statistics Research Laboratory, Department of Anesthesia and Critical CareMassachusetts General HospitalBostonUSA
  5. 5.MIT-Harvard Division of Health Sciences and TechnologyMassachusetts Institute of TechnologyCambridgeUSA

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