Biological Cybernetics

, Volume 89, Issue 2, pp 81–88

A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations


DOI: 10.1007/s00422-003-0425-7

Cite this article as:
Tass, P. Biol. Cybern. (2003) 89: 81. doi:10.1007/s00422-003-0425-7


The coordinated reset of neural subpopulations is introduced as an effectively desynchronizing stimulation technique. For this, short sequences of high-frequency pulse trains are administered at different sites in a coordinated way. Desynchronization is easily maintained by performing a coordinated reset with demand-controlled timing or by periodically administering resetting high-frequency pulse trains of demand-controlled length. Unlike previously developed methods, this novel approach is robust against variations of model parameters and does not require time-consuming calibration. The novel technique is suggested to be used for demand-controlled deep brain stimulation in patients suffering from Parkinson's disease or essential tremor. It might even be applicable to diseases with intermittently emerging synchronized neural oscillations like epilepsy.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  1. 1.Research Center JülichInstitute of MedicineJülichGermany
  2. 2.Department of Stereotaxic and Functional NeurosurgeryUniversity of CologneCologneGermany

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