Biological Cybernetics

, Volume 89, Issue 2, pp 81–88 | Cite as

A model of desynchronizing deep brain stimulation with a demand-controlled coordinated reset of neural subpopulations

  • Peter A. TassEmail author


The coordinated reset of neural subpopulations is introduced as an effectively desynchronizing stimulation technique. For this, short sequences of high-frequency pulse trains are administered at different sites in a coordinated way. Desynchronization is easily maintained by performing a coordinated reset with demand-controlled timing or by periodically administering resetting high-frequency pulse trains of demand-controlled length. Unlike previously developed methods, this novel approach is robust against variations of model parameters and does not require time-consuming calibration. The novel technique is suggested to be used for demand-controlled deep brain stimulation in patients suffering from Parkinson's disease or essential tremor. It might even be applicable to diseases with intermittently emerging synchronized neural oscillations like epilepsy.


Deep Brain Stimulation Brain Stimulation Pulse Train Essential Tremor Short Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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This study was supported by the German-Israeli Foundation for Scientific Research and Development (Grant No. 667/00).

Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  1. 1.Research Center JülichInstitute of MedicineJülichGermany
  2. 2.Department of Stereotaxic and Functional NeurosurgeryUniversity of CologneCologneGermany

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