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Leg extensor power and dehydroepiandrosterone sulfate, insulin-like growth factor-I and testosterone in healthy active elderly people

  • Tomasz Kostka
  • Laurent M. Arsac
  • Marie C. Patricot
  • Sophie E. Berthouze
  • Jean-René Lacour
  • Marc Bonnefoy
ORIGINAL ARTICLE

Abstract

We examined the association between quadriceps muscle function and serum levels of dehydroepiandrosterone sulphate (DHEAS), insulin-like growth factor I (IGF-I) and testosterone in a group of healthy elderly people. Fifty-three independent, community-dwelling elderly subjects (26 men and 27 women) aged from 66 to 84 years volunteered to participate in the study. Physical activity (PA) was evaluated by a questionnaire. Quadriceps maximal muscle power (max) and optimal shortening velocity (vopt) were measured on a friction-loaded non-isokinetic cycle ergometer. The max is expressed in relation to body mass (max/kg, W · kg−1), and in relation to the mass of the two quadriceps muscles (max/Quadr, W · kgQuadr−1). In women, when adjusted for age, anthropometric measurements and PA indices, IGF-I correlated significantly with max/kg (partial correlation: r=0.59; P=0.001), max/Quadr (r=0.58; P=0.002) and vopt (r=0.53; P=0.004), whereas DHEAS was correlated significantly with max/kg (r=0.54; P=0.003) and max/Quadr (r=0.58; P=0.002). No such correlation was found in men. These findings indicate that in healthy elderly women lower values for quadriceps muscle max and vopt are related, independently of age, anthropometric measurements and PA indices, to lower circulating levels of DHEAS and IGF-I.

Key words Ageing Hormone Fitness Exercise Muscle strength 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • Tomasz Kostka
    • 1
  • Laurent M. Arsac
    • 2
  • Marie C. Patricot
    • 3
  • Sophie E. Berthouze
    • 4
  • Jean-René Lacour
    • 2
  • Marc Bonnefoy
    • 1
  1. 1.Service de Médecine Gériatrique, Centre Hospitalier Lyon-Sud, 69495 Pierre-Bénite Cedex, Lyon, FranceFR
  2. 2.Laboratoire de Physiologie – GIP Exercice, Faculté de Médecine de Lyon-Sud, Lyon, FranceFR
  3. 3.Laboratoire de Biochimie (Pr A. Revol), Centre Hospitalier Lyon-Sud, Lyon, FranceFR
  4. 4.Département de Rééducation et Réadaptation Fonctionnelles – GIP Exercice, Faculté de Médecine, Université Jean Monnet, Saint-Etienne, FranceFR

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