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Physiological responses to hypoxic constant-load and high-intensity interval exercise sessions in healthy subjects

  • S. Chacaroun
  • I. Vega-Escamilla y Gonzalez
  • P. Flore
  • S. Doutreleau
  • Samuel Verges
Original Article

Abstract

Purpose

The aim of this study was to assess the acute cardiorespiratory as well as muscle and cerebral tissue oxygenation responses to submaximal constant-load (CL) and high-intensity interval (HII) cycling exercise performed in normoxia and in hypoxia at similar intensity, reproducing whole-body endurance exercise training sessions as performed in sedentary and clinical populations.

Methods

Healthy subjects performed two CL (30 min, 75% of maximal heart rate, n = 12) and two HII (15 times 1-min high-intensity exercise—1-min passive recovery, n = 12) cycling exercise sessions in normoxia and in hypoxia [mean arterial oxygen saturation 76 ± 1% (clamped) during CL and 77 ± 5% (inspiratory oxygen fraction 0.135) during HII]. Cardiorespiratory and near-infrared spectroscopy parameters as well as the rate of perceived exertion were continuously recorded.

Results

Power output was 21 ± 11% and 15% (according to protocol design) lower in hypoxia compared to normoxia during CL and HII exercise sessions, respectively. Heart rate did not differ between normoxic and hypoxic exercise sessions, while minute ventilation was higher in hypoxia during HII exercise only (+ 13 ± 29%, p < 0.05). Quadriceps tissue saturation index did not differ significantly between normoxia and hypoxia (CL 60 ± 8% versus 59 ± 5%; HII 59 ± 10% versus 56 ± 9%; p > 0.05), while prefrontal cortex deoxygenation was significantly greater in hypoxia during both CL (66 ± 4% versus 56 ± 6%) and HII (58 ± 5% versus 55 ± 5%; p < 0.05) sessions. The rate of perceived exertion did not differ between normoxic and hypoxic CL (2.4 ± 1.7 versus 2.9 ± 1.8) and HII (6.9 ± 1.4 versus 7.5 ± 0.8) sessions (p > 0.05).

Conclusion

This study indicates that at identical heart rate, reducing arterial oxygen saturation near 75% does not accentuate muscle deoxygenation during both CL and HII exercise sessions compared to normoxia. Hence, within these conditions, larger muscle hypoxic stress should not be expected.

Keywords

Constant-load exercise High-intensity exercise Hypoxia Muscle oxygenation Cerebral oxygenation 

Abbreviations

ANOVA

Analysis of variance

CL

Constant-load exercise

FiO2

Inspiratory oxygen fraction

HbO2

Oxygenated hemoglobin

HbTot

Total hemoglobin

HHb

Deoxygenated hemoglobin

HII

High-intensity interval exercise

NIRS

Near-infrared spectroscopy

RPE

Rate of perceived exertion

SpO2

Arterial oxygen saturation

TSI

Tissue oxygenation index

Notes

Acknowledgements

We thank all the subjects for participating to this study, the “Fond de Dotation Agir pour les maladies chroniques” for financial support and the Lebanese University for their support with a PhD grant (CS).

Compliance with ethical standards

Conflict of interest

All authors declare to have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.HP2 Laboratory, INSERM U1042, UM Sports Pathologies, Hôpital SudUniv. Grenoble AlpesEchirollesFrance
  2. 2.Grenoble Alpes University HospitalGrenobleFrance

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