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European Journal of Applied Physiology

, Volume 118, Issue 11, pp 2417–2427 | Cite as

Cerebral oxygenation declines but does not impair peak oxygen uptake during incremental cycling in women using oral contraceptives

  • Karlee M. Quinn
  • François Billaut
  • Andrew C. Bulmer
  • Clare L. Minahan
Original Article
  • 45 Downloads

Abstract

Purpose

To compare prefrontal cortex oxygenation in recreationally-active women using oral contraceptives (WomenOC; n = 8) to women with a natural menstrual cycle (WomenNC; n = 8) during incremental exercise to exhaustion.

Methods

Participants performed incremental cycling to exhaustion to determine lactate threshold 1 (LT1) and 2 (LT2) and peak oxygen uptake (VO2peak). Prefrontal cortex oxygenation was monitored via near-infrared spectroscopy through concentration changes in oxy-haemoglobin (Δ[HbO2]), deoxy-haemoglobin (Δ[HHb]), total-haemoglobin (Δ[tHb]) and tissue saturation index (TSI).

Results

17β-oestradiol and progesterone were lower in WomenOC (35 ± 26; 318 ± 127 pmol·L−1, respectively) than WomenNC (261 ± 156; 858 ± 541 pmol·L−1, respectively). There were no differences in full blood examination results or serum nitric oxide (p > 0.05). However, WomenOC presented lower concentrations in ferric-reducing ability of plasma (− 8%; effect size; ES − 0.52 ± 0.61), bilirubin (− 32%; ES − 0.56 ± 0.62) and uric acid (− 17%; ES − 0.53 ± 0.61). Cardiopulmonary parameters were similar between groups during cycling, including VO2peak (p = 0.99). While there was a significant effect of time on all parameters measured by near-infrared spectroscopy during incremental cycling, there was no effect of OC at LT1, LT2 or exhaustion calculated as a change from baseline (TSI; p = 0.096, Δ[HbO2]; p = 0.143, Δ[HHb]; p = 0.085 and Δ[tHb]; p = 0.226). The change in TSI from LT1 to LT2 was significantly different between groups (WomenNC; mean difference + 2.06%, WomenOC; mean difference − 1.73%; p = 0.003).

Conclusion

Prefrontal tissue oxygenation declined at a lower relative exercise intensity in WomenOC as compared to WomenNC, however, this did not influence VO2peak. The results provide the first evidence for variance in the cerebral oxygenation response to exercise, which may be associated with female sex hormones.

Keywords

Contraceptives Oral Female Aerobic exercise Near infrared spectroscopy Prefrontal cortex 

Abbreviations

b·min−1

Beat per minute

d

Day(s)

FRAP

Ferric-reducing ability of plasma

g·L−1

Gram per litre

h

Hour(s)

HbO2

Oxygenated haemoglobin

HHb

Deoxygenated haemoglobin

Hz

Hertz

kg

Kilogram

kg·m−2

Kilogram per square meter

[La]

Lactate concentration

L·min− 1

Litres per minute

LT1

Lactate threshold 1

LT2

Lactate threshold 2

min

Minute(s)

min·week− 1

Minutes per week

mL·kg·min− 1

Millilitres per kilogram per minute

mmol·L− 1

Millimoles per litre

mmHg

Millimeter of mercury

NIRS

Near-infrared spectroscopy

NO

Nitric oxide

OC

Oral contraceptives

pmol·L−1

Picomole per litre

rev·min− 1

Revolutions per minute

ROS

Reactive oxygen species

RPE

Rate of perceived exertion

s

Second(s)

tHb

Total haemoglobin

TSI

Tissue saturation index

VO2

Oxygen uptake

VO2peak

Peak oxygen uptake

W

Watt(s)

wk

Week(s)

WomenNC

Women with a natural menstrual cycle

WomenOC

Women using combined, monophasic oral contraceptives

yr

Year(s)

Δ

Change or difference

%

Percent

μM·Fe

Micromole of iron

μmol·L−1

Micomole per litre

Notes

Acknowledgements

This study was funded by Sport Performance Innovation and Knowledge Excellence unit, Queensland Academy of Sport.

Author contributions

Conception or design of the work: KQ, CM. Acquisition, analysis or interpretation of data: KQ, CM, FB, AB. Drafting of the work or revising it critically for important intellectual content: KQ, CM, FB, AB. All authors approved the final version of the manuscript and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All persons designated as authors qualify for authorship, and all those who qualify for authorship are listed.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Griffith Sports Physiology and Performance, Gold Coast campus, School of Allied Health SciencesGriffith UniversityGold CoastAustralia
  2. 2.Menzies Health Institute QueenslandGriffith UniversityGold CoastAustralia
  3. 3.Queensland Academy of SportNathanAustralia
  4. 4.Department of Kinesiology, Faculty of MedicineLaval UniversityQuebecCanada
  5. 5.School of Medical ScienceGriffith UniversityGold CoastAustralia

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