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European Journal of Applied Physiology

, Volume 118, Issue 11, pp 2281–2293 | Cite as

Effects of endurance training on neuromuscular fatigue in healthy active men. Part I: Strength loss and muscle fatigue

  • J. Mira
  • S. J. Aboodarda
  • M. Floreani
  • R. Jaswal
  • S. J. Moon
  • K. Amery
  • T. Rupp
  • Guillaume Y. Millet
Original Article

Abstract

Purpose

The adaptations induced by endurance training on the neuromuscular function remain under investigation and, for methodological reasons, unclear. This study investigates the effects of cycling training on neuromuscular fatigue and its peripheral contribution measured during and immediately after cycling exercise.

Methods

Fourteen healthy men performed a fatigue test before a 9-week cycling program (PRE) and two tests after training: at the same absolute power output as PRE (POSTABS) and based on the post-training maximal aerobic power (POSTREL). Throughout the tests and at exhaustion (EXH), maximal voluntary contraction (MVC) and peripheral fatigue were assessed in the quadriceps muscle by electrical nerve stimulation [single twitch (Pt); high-frequency doublet (Db100) and low-to-high-frequency ratio (Db10:100)].

Results

Time to EXH was longer in POSTABS than PRE (34 ± 5 vs. 27 ± 4 min, P < 0.001), and POSTREL tended to be longer than PRE (30 ± 6 min, P = 0.053). MVC and peripheral fatigue were overall less depressed in POSTABS than PRE at isotime. At EXH, MVC and Db10:100 were similarly reduced in all sessions (–37 to − 42% and − 30 to − 37%, respectively). Db100 tended to be less depressed in POSTABS than PRE (–40 ± 9 vs. − 48 ± 16%, P = 0.050) and in POSTREL than PRE (–39 ± 9%, P = 0.071). Pt decreased similarly in POSTABS and PRE (–52 ± 16 vs. − 54 ± 16%), but POSTREL tended to be less depressed than PRE (–48 ± 14%, P = 0.075).

Conclusions

This study confirms fatigue attenuation at isotime after training. Yet lower or similar fatigue at EXH indicates that, unlike previously suggested, fatigue tolerance may not be upregulated after 9 weeks of cycling training.

Keywords

Aerobic training Excitation–contraction coupling failure Neuromuscular function Peripheral fatigue 

Abbreviations

CST

Constant-load submaximal training

Db10

Low-frequency doublet

Db10:100

Low-frequency fatigue

Db100

High-frequency doublet

ECC

Excitation–contraction coupling

EXH

Exhaustion

GET

Gas exchange threshold

HIIT

High-intensity interval training

HR

Heart rate

La

Lactate

MVC

Maximal voluntary contraction

NMF

Neuromuscular fatigue

POSTABS

Fatigue session based on the same absolute power output as before training

POSTREL

Fatigue session based on the same relative intensity as before training

PRE

Initial fatigue test

Pt

Peak twitch

RCP

Respiratory compensation point

RPE

Rate of perceived exertion

SERCA

Sarco(endo)plasmic reticulum Ca2+ ATPase

TMS

Transcranial magnetic stimulation

TTE

Time to exhaustion

TTEPRE

TTE of PRE

\(\dot {V}\)CO2

CO2 output

\(\dot {V}\)E

Minute ventilation

\(\dot {V}\)E/\(\dot {V}\)CO2

Ventilatory equivalent of V̇CO2

\(\dot {V}\)O2max

Maximal oxygen uptake

\(\dot {V}\)O2peak

Peak \(\dot {V}\)O2

Wmax

Maximal aerobic power output

Notes

Author contribution statement

TR, GYM, SJA, and JM conceived and designed the research. SJA, JM, MF, RJ, SJM, and KA conducted the experiment and analyzed data. JM wrote the manuscript. All authors read and approved the manuscript.

Funding

This study was supported by the Université Savoie Mont Blanc as part of the doctoral work of José Mira. Saied Jalal Aboodarda was funded by the Eyes High Postdoctoral Scholars.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • J. Mira
    • 1
    • 2
  • S. J. Aboodarda
    • 1
  • M. Floreani
    • 1
    • 3
  • R. Jaswal
    • 1
  • S. J. Moon
    • 1
  • K. Amery
    • 1
  • T. Rupp
    • 2
  • Guillaume Y. Millet
    • 1
  1. 1.Human Performance Laboratory, Faculty of KinesiologyUniversity of CalgaryCalgaryCanada
  2. 2.Laboratoire Interuniversitaire de Biologie de la MotricitéUniversité Savoie Mont BlancChambéryFrance
  3. 3.Department of Medical and Biological SciencesUniversity of UdineUdineItaly

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