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European Journal of Applied Physiology

, Volume 118, Issue 9, pp 2007–2019 | Cite as

Overall and differentiated sensory responses to cardiopulmonary exercise test in patients with cystic fibrosis: kinetics and ability to predict peak oxygen uptake

  • Mathieu GruetEmail author
  • Laurent Mely
  • Jean-Marc Vallier
Original Article

Abstract

Purpose

We evaluated the validity of predicting peak oxygen uptake (\(\dot {V}\)O2peak) from submaximal ratings of perceived exertion (RPE) during incremental cardiopulmonary exercise test (CPET) in patients with cystic fibrosis (CF) and compared the predictive accuracy between overall and differentiated RPE scores.

Methods

Thirty-five adults with CF (FEV1 = 58 ± 23%) performed a CPET on cycle ergometer with gas exchange measurements. Leg, chest and overall RPE were collected every minute throughout the test. Linear regressions between \(\dot {V}\)O2 and RPE ≤ 15 were extrapolated to maximal theoretical RPE (i.e. RPE18 and RPE19) to predict \(\dot {V}\)O2peak. Agreements between measured and all predicted \(\dot {V}\)O2peak were tested using Bland–Altman Plots, for the whole group and for subjects presenting significant exercise intolerance (n = 24).

Results

Leg, chest and overall RPE increased similarly with exercise intensity. No differences were found between predicted \(\dot {V}\)O2peak and measured \(\dot {V}\)O2peak with RPE18 as maximal RPE, for both overall and differentiated RPE (P range 0.94–0.98). Ranges for Pearson correlations and limits of agreements were 0.88–0.91 and 380–461 mL min−1 for the whole group and 0.92–0.94 and 269–365 mL min−1 for subjects with significant exercise intolerance. The greatest association and narrowest limits of agreements were obtained from chest RPE scores.

Conclusions

Submaximal RPE scores obtained during CPET can provide acceptable estimate of \(\dot {V}\)O2peak in adults with CF, particularly in those having significant exercise intolerance. Future studies should assess whether the prediction can be improved, particularly by encouraging the regular use of RPE scales during physical activities/exercise rehabilitations sessions.

Keywords

Cystic fibrosis Physical functioning Rating of perceived exertion Peak aerobic capacity 

Abbreviations

BRImax

Breathing reserve index at maximum exercise

CF

Cystic fibrosis

COPD

Chronic obstructive pulmonary disease

CPET

Cardiopulmonary exercise test

CR-10

Category-ratio 10

HR

Heart rate

FEV1

Forced expiratory volume in 1 s

LoA

Limits of agreement

PA

Physical activity

RPE

Ratings of perceived exertion

RPE-C

Chest RPE

RPE-L

Leg RPE

RPE-O

Overall RPE

\(\dot {V}\)O2peak

Peak oxygen uptake

Notes

Acknowledgements

We are grateful to Nadège Goriot-Raynaud and Alicia Bordel for their support during this study.

Author contributions

MG contributed to study design, literature search, data collection, data analysis, manuscript writing and review. LM contributed to study design, data collection, data analysis and manuscript review. JMV contributed to study design, literature search, data collection, data analysis, and manuscript review. All authors read and approved the manuscript.

Funding

None.

Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest to declare.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Mathieu Gruet
    • 1
    Email author
  • Laurent Mely
    • 1
    • 2
  • Jean-Marc Vallier
    • 1
  1. 1.Université de Toulon, LAMHESSToulonFrance
  2. 2.Hôpital Renée Sabran, CRCMGiensFrance

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