Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS)
- 1.8k Downloads
Oral curcumin decreases inflammatory cytokines and increases muscle regeneration in mice.
To determine effects of curcumin on muscle damage, inflammation and delayed onset muscle soreness (DOMS) in humans.
Seventeen men completed a double-blind randomized-controlled crossover trial to estimate the effects of oral curcumin supplementation (2.5 g twice daily) versus placebo on single-leg jump performance and DOMS following unaccustomed heavy eccentric exercise. Curcumin or placebo was taken 2 d before to 3 d after eccentric single-leg press exercise, separated by 14-d washout. Measurements were made at baseline, and 0, 24 and 48-h post-exercise comprising: (a) limb pain (1–10 cm visual analogue scale; VAS), (b) muscle swelling, (c) single-leg jump height, and (d) serum markers of muscle damage and inflammation. Standardized magnitude-based inference was used to define outcomes.
At 24 and 48-h post-exercise, curcumin caused moderate-large reductions in pain during single-leg squat (VAS scale −1.4 to −1.7; 90 %CL: ±1.0), gluteal stretch (−1.0 to −1.9; ±0.9), squat jump (−1.5 to −1.1; ± 1.2) and small reductions in creatine kinase activity (−22–29 %; ±21–22 %). Associated with the pain reduction was a small increase in single-leg jump performance (15 %; 90 %CL ± 12 %). Curcumin increased interleukin-6 concentrations at 0-h (31 %; ±29 %) and 48-h (32 %; ±29 %) relative to baseline, but decreased IL-6 at 24-h relative to post-exercise (−20 %; ±18 %).
Oral curcumin likely reduces pain associated with DOMS with some evidence for enhanced recovery of muscle performance. Further study is required on mechanisms and translational effects on sport or vocational performance.
KeywordsPerformance Eccentric exercise Inflammation Recovery Visual analogue scale
Activator protein 1
Australian Institute of Sport
Delayed onset muscle soreness
- NF kappa B
Nuclear factor kappa beta
One repetition maximum
Tumour necrosis factor alpha
Visual analogue scale
Dr Greg Lovell, Bev Andersen, Jill Flanagan, Dr Chris Rumball, Dr Kieran Fallon, and all staff at AIS Sports Medicine Department. Funding from the Australian Institute of Sport. Dr Lesley Nicol is a board member of Drug Free Sport New Zealand. Other authors have no disclosures.
- Batterham AM, Hopkins WG (2006) Making meaningful inferences about magnitudes. Int J Sport Physiol Perf 1(1):50–57Google Scholar
- Buhrmann C, Mobasheri A, Busch F, Aldinger C, Stahlmann R, Montaseri A, Shakibaei M (2011) Curcumin Modulates nuclear factor κB (NF-κB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/akt pathway. J Biol Chem 286(32):28556–28566. doi: 10.1074/jbc.M111.256180 PubMedCentralPubMedCrossRefGoogle Scholar
- Davis JM, Murphy EA, Carmichael MD, Zielinski MR, Groschwitz CM, Brown AS, Gangemi JD, Ghaffar A, Mayer EP (2007) Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol 292(6):R2168–R2173PubMedCrossRefGoogle Scholar
- Hopkins WG (2006) Estimating sample size for magnitude-based inferences. Sportscience 10:60–63Google Scholar
- Rowlands DS, Rossler K, Thorp RM, Graham D, Timmons BW, Stannard S, Tarnopolsky MA (2008a) Effect of dietary protein content during recovery from high-intensity cycling on subsequent performance and markers of stress, inflammation, and muscle damage in well-trained men. Appl Physiol Nutr Metabol 33:39–51CrossRefGoogle Scholar
- Rowlands DS, Rossler K, Thorp RM, Graham DF, Timmons DW, Stannard SR, Tarnopolsky MA (2008b) Effect of dietary protein content during recovery from high-intensity cycling on subsequent performance and markers of stress, inflammation, and muscle damage in well-trained men. Appl Physiol Nutr Metabol 33:39–51CrossRefGoogle Scholar
- Rowlands DS, Nelson AR, Phillips SM, Faulkner JA, Clarke J, Burd NA, Moore D (2014) Stellingwerff T (2014) Protein-leucine fed dose effects on muscle protein synthesis after endurance exercise. Med Sci Sports Exerc 46(5):98–99Google Scholar