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European Journal of Applied Physiology

, Volume 114, Issue 8, pp 1737–1748 | Cite as

Resistance exercise training-induced decrease in circulating inflammatory CD14+CD16+ monocyte percentage without weight loss in older adults

  • Melissa M. Markofski
  • Michael G. Flynn
  • Andres E. Carrillo
  • Cheryl L. H. Armstrong
  • Wayne W. Campbell
  • Darlene A. Sedlock
Original Article

Abstract

Purpose

Exercise training reduces systemic inflammation in weight-stable people, but concurrent diet-induced body weight loss is not well studied. We hypothesized that resistance training would decrease inflammatory monocyte percentage and improve biomarkers associated with disease risk, independent of weight loss.

Methods

Forty physically inactive (PI) subjects (58.0 ± 5.7 years; BMI 30.1 ± 4.3 kg m−2) completed baseline testing, and 26 of these subjects completed 12-week of resistance training exercises while consuming either their usual, weight-maintenance diet (RE, n = 14) or an energy-restricted diet (RE–ER, n = 12). Nine physically active (PA) subjects served as a comparison group (60.1 ± 6.1 years; BMI 25.8 ± 3.1 kg m−2).

Results

At baseline, circulating CD14+CD16+ monocyte percentage, C-reactive protein, and cholesterol were higher in PI vs. PA. Post-intervention, RE subjects had a ~35 % decrease in circulating CD14+CD16+, and a lower LPS-stimulated TNFα and IL-6 production, while RE–ER subjects had lower cholesterol than RE.

Conclusions

These findings indicate that resistance training is an effective means for older, overweight adults to reduce systemic inflammation. The unexpected lack of response with concurrent energy restriction underscores the need for further research on the use of resistance training and diet to reduce inflammation.

Keywords

Resistance exercise Inflammation Adiponectin Cytokine 

Abbreviations

BMI

Body mass index

CRP

C-reactive protein

RE

Resistance exercise group

RE–ER

Resistance exercise and energy restriction group

IL

Interleukin

LPS

Lipopolysaccharide

MFI

Mean fluorescence intensity

PA

Physically active

PI

Physically inactive

PMB

Polymixin B

TLR

Toll-like receptor

TNF

Tumor necrosis factor

Notes

Acknowledgments

This research was conducted at Purdue University, West Lafayette, Indiana. Support for this project was provided by the National Institutes of Health, Indiana Clinical and Translational Sciences Institute, Indiana Clinical Research Center at Purdue University, UL RR025761; The Purdue University Ismail Center for Health, Exercise, and Nutrition; the Department of Health and Kinesiology at Purdue University; and a Bilsland Dissertation Fellowship (for MMM) from Purdue University.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Melissa M. Markofski
    • 1
  • Michael G. Flynn
    • 2
  • Andres E. Carrillo
    • 3
  • Cheryl L. H. Armstrong
    • 4
  • Wayne W. Campbell
    • 4
  • Darlene A. Sedlock
    • 5
  1. 1.Sealy Center on Aging, University of Texas Medical Branch at GalvestonGalvestonUSA
  2. 2.Department of Health and Human PerformanceCollege of CharlestonCharlestonUSA
  3. 3.Department of Exercise ScienceChatham UniversityPittsburghUSA
  4. 4.Department of Nutrition SciencePurdue UniversityWest LafayetteUSA
  5. 5.Department of Health and KinesiologyPurdue UniversityWest LafayetteUSA

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