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European Journal of Applied Physiology

, Volume 114, Issue 7, pp 1545–1553 | Cite as

Changes in corticospinal excitability during an acute bout of resistance exercise in the elbow flexors

  • Ilona Ruotsalainen
  • Juha P. Ahtiainen
  • Dawson J. Kidgell
  • Janne AvelaEmail author
Original Article

Abstract

Purpose

Hypertrophic resistance exercise (HRE) induces central and peripheral fatigue. However, more detailed information about changes in corticospinal excitability remains to be elucidated.

Methods

Eleven volunteers participated in the upper arm HRE which included one repetition maximum (1 RM) control contractions and three sets of 13 RM (SET1–3). Transcranial magnetic stimulation (TMS) was applied during maximal isometric voluntary contraction (MVC) at the end of each set and during control contractions to study changes in corticospinal excitability. Electrical stimulation was used in order to measure peripheral changes.

Results

MVC decreased after each set when compared to control contractions. Motor evoked potential (MEP) were 138.7 ± 52.7 % (p < 0.05), 130.4 ± 44.7 and 113.1 ± 31.4 % after SET1, SET2 and SET3, respectively, when compared to pre-exercise value. A significant reduction in MEP area between SET1 and SET3 (p < 0.05) was observed while silent period (SP) duration increased (~151–165 ms, p < 0.05) simultaneously between these sets. TMS-evoked twitch force during MVC increased significantly following each set when compared to pre-exercise value. Simultaneously, a significant reduction was observed in resting twitch force over the sets.

Conclusions

The results of this study clearly support the existence of both central and peripheral fatigue during HRE of elbow flexors. However, changes in the MEP area and SP suggest that during HRE of the elbow flexors, the corticospinal excitability increases first, until at some point, supraspinal fatigue takes over.

Keywords

Transcranial magnetic stimulation Neuromuscular responses Strength training Electromyography Fatigue 

Abbreviations

CMEPs

Cervicomedullary motor evoked potentials

CV

Coefficient of variation

EMG

Electromyography

GABAB receptors

Metabotropic transmembrane receptors for gamma-aminobutyric acid

HRE

Hypertrophic resistance exercise

MEP

Motor evoked potential

Mmax

Maximal M-wave

MVC

Maximal voluntary contraction

RM

Repetition maximum

RMT

Resting motor threshold

SP

Silent period

TMS

Transcranial magnetic stimulation

TWpas

Passive twitch evoked by electrical stimulation

TWsup

Superimposed twitch evoked by TMS

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Ilona Ruotsalainen
    • 1
  • Juha P. Ahtiainen
    • 1
  • Dawson J. Kidgell
    • 2
  • Janne Avela
    • 1
    Email author
  1. 1.Neuromuscular Research Center, Department of Biology of Physical ActivityUniversity of JyväskyläJyväskyläFinland
  2. 2.Centre for Physical Activity and Nutrition ResearchDeakin UniversityMelbourneAustralia

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