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European Journal of Applied Physiology

, Volume 114, Issue 5, pp 1075–1084 | Cite as

Muscle damage responses and adaptations to eccentric-overload resistance exercise in men and women

  • Rodrigo Fernandez-Gonzalo
  • Tommy R. Lundberg
  • Lucia Alvarez-Alvarez
  • José A. de Paz
Original Article

Abstract

Purpose

This study assessed markers of muscle damage and training adaptations to eccentric-overload flywheel resistance exercise (RE) in men and women.

Methods

Dynamic strength (1 RM), jump performance, maximal power at different percentages of 1 RM, and muscle mass in three different portions of the thigh were assessed in 16 men and 16 women before and after 6 weeks (15 sessions) of flywheel supine squat RE training. Plasma creatine kinase (CK) and lactate dehydrogenase (LDH) concentrations were measured before, 24, 48 and 72 h after the first and the last training session.

Results

After training, increases in 1 RM were somewhat greater (interaction P < 0.001) in men (25 %) than in women (20 %). Squat and drop jump height and power performance at 50, 60, 70 and 80 % of 1 RM increased after training in both sexes (P < 0.05). Power improvement at 80 % of 1 RM was greater (interaction P < 0.02) in men than women. Muscle mass increased ~5 % in both groups (P < 0.05). CK increased in men after the first training session (P < 0.001), whereas the response in women was unaltered. In both sexes, LDH concentration was greater after the first training session compared with basal values (P < 0.05). After the last session, CK and LDH remained at baseline in both groups.

Conclusions

These results suggest that although improvements in maximal strength and power at high loads may be slightly greater for men, eccentric-overload RE training induces comparable and favorable gains in strength, power, and muscle mass in both men and women. Equally important, it appears muscle damage does not interfere with the adaptations triggered by this training paradigm.

Keywords

1 RM Power Muscle hypertrophy CK LDH 

Abbreviations

ANOVA

Analysis of variance

CK

Creatine kinase

CMJ

Countermovement jump

CON

Concentric

DJ

Drop jump

DXA

Dual energy X-ray absorptiometry

ECC

Eccentric

LDH

Lactate dehydrogenase

MRI

Magnetic resonance imaging

RE

Resistance exercise

RM

Repetition maximum

SEM

Standard error of the mean

SJ

Squat jump

Notes

Acknowledgments

This study was partly funded by Consejería de Educación, Junta de Castilla y León, Spain.

Conflict of interest

The authors declare no conflicts of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Rodrigo Fernandez-Gonzalo
    • 1
    • 2
  • Tommy R. Lundberg
    • 3
  • Lucia Alvarez-Alvarez
    • 2
  • José A. de Paz
    • 2
  1. 1.Department of Physiology and PharmacologyKarolinska InstitutetStockholmSweden
  2. 2.Institute of Biomedicine (IBIOMED)University of LeónLeónSpain
  3. 3.Department of Health SciencesMid Sweden UniversityÖstersundSweden

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