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European Journal of Applied Physiology

, Volume 114, Issue 5, pp 1013–1023 | Cite as

Adaptations of aortic and pulmonary artery flow parameters measured by phase-contrast magnetic resonance angiography during supine aerobic exercise

  • Guido E. PielesEmail author
  • Gergely Szantho
  • Jonathan C. L. Rodrigues
  • Christopher B. Lawton
  • A. Graham Stuart
  • Chiara Bucciarelli-Ducci
  • Mark S. Turner
  • Craig A. Williams
  • Robert M. R. Tulloh
  • Mark C. K. Hamilton
Original Article

Abstract

Purpose

Increased oxygen uptake and utilisation during exercise depend on adequate adaptations of systemic and pulmonary vasculature. Recent advances in magnetic resonance imaging techniques allow for direct quantification of aortic and pulmonary blood flow using phase-contrast magnetic resonance angiography (PCMRA). This pilot study tested quantification of aortic and pulmonary haemodynamic adaptations to moderate aerobic supine leg exercise using PCMRA.

Methods

Nine adult healthy volunteers underwent pulse gated free breathing PCMRA while performing heart rate targeted aerobic lower limb exercise. Flow was assessed in mid ascending and mid descending thoracic aorta (AO) and main pulmonary artery (MPA) during exercise at 180 % of individual resting heart rate. Flow sequence analysis was performed by experienced operators using commercial offline software (Argus, Siemens Medical Systems).

Results

Exercise related increase in HR (rest: 69 ± 10 b min−1, exercise: 120 ± 13 b min−1) resulted in cardiac output increase (from 6.5 ± 1.4 to 12.5 ± 1.8 L min−1). At exercise, ascending aorta systolic peak velocity increased from 89 ± 14 to 122 ± 34 cm s−1 (p = 0.016), descending thoracic aorta systolic peak velocity increased from 104 ± 14 to 144 ± 33 cm s−1 (p = 0.004), MPA systolic peak velocity from 86 ± 18 to 140 ± 48 cm s−1 (p = 0.007), ascending aorta systolic peak flow rate from 415 ± 83 to 550 ± 135 mL s−1 (p = 0.002), descending thoracic aorta systolic peak flow rate from 264 ± 70 to 351 ± 82 mL s−1 (p = 0.004) and MPA systolic peak flow rate from 410 ± 80 to 577 ± 180 mL s−1 (p = 0.006).

Conclusion

Quantitative blood flow and velocity analysis during exercise using PCMRA is feasible and detected a steep exercise flow and velocity increase in the aorta and MPA. Exercise PCMRA can serve as a research and clinical tool to help quantify exercise blood flow adaptations in health and disease and investigate patho-physiological mechanisms in cardio-pulmonary disease.

Keywords

Exercise adaptations Blood flow Magnetic resonance imaging Imaging methodology Feasibility Cardio-pulmonary disease 

Abbreviations

Ao

Aorta

CPET

Cardio-pulmonary exercise test

FOV

Field of view

MRI

Magnetic resonance imaging

PA

Pulmonary artery

PAH

Pulmonary arterial hypertension

PCMRA

Phase-contrast magnetic resonance angiography

PVR

Pulmonary vascular resistance

RV

Right ventricle

TE

Echo time

TR

Repetition time

VENC

Velocity encoding

Notes

Acknowledgments

The study was supported and hosted by the Bristol NIHR Biomedical Research Unit for Cardiovascular Disease. GEP holds a NIHR/University of Bristol Academic Clinical Lectureship. We express our gratitude to C. Rogers for statistical support.

Conflict of interest

None of the authors declare any conflict of interest.

Supplementary material

Supplementary material 1 (MOV 26264 kb)

Supplementary material 2 (AVI 3366 kb)

Supplementary material 3 (AVI 3395 kb)

421_2014_2833_MOESM4_ESM.docx (61 kb)
Supplementary material 4 (DOCX 61 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Guido E. Pieles
    • 1
    • 2
    Email author
  • Gergely Szantho
    • 1
  • Jonathan C. L. Rodrigues
    • 3
  • Christopher B. Lawton
    • 3
  • A. Graham Stuart
    • 1
  • Chiara Bucciarelli-Ducci
    • 2
  • Mark S. Turner
    • 1
  • Craig A. Williams
    • 4
  • Robert M. R. Tulloh
    • 1
  • Mark C. K. Hamilton
    • 2
    • 3
  1. 1.Congenital Heart UnitBristol Royal Hospital for Children/Bristol Heart InstituteBristolUK
  2. 2.National Institute for Health Research (NIHR), Cardiovascular Biomedical Research UnitBristol Heart Institute, Bristol Royal InfirmaryBristolUK
  3. 3.Department of RadiologyBristol Royal InfirmaryBristolUK
  4. 4.Children’s Health and Exercise Research Centre (CHERC), College of Life and Environmental Sciences, St. Luke’s CampusUniversity of ExeterExeterUK

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