European Journal of Applied Physiology

, Volume 114, Issue 3, pp 579–586 | Cite as

Blood pressure regulation XI: overview and future research directions

  • Peter B. RavenEmail author
  • Mark W. Chapleau
Invited Review


While the importance of regulating arterial blood pressure within a ‘normal’ range is widely appreciated, the definition of ‘normal’ and the means by which humans and other species regulate blood pressure under various conditions remain hotly debated. The effects of diverse physiological, pathological and environmental challenges on blood pressure and the mechanisms that attempt to maintain it at an optimal level are reviewed and critically analyzed in a series of articles published in this themed issue of the European Journal of Applied Physiology. We summarize here the major points made in these reviews, with emphasis on unifying concepts of regulatory mechanisms and future directions for research.


Arterial baroreflex resetting Cardiac output Hemodynamic responses Hypertension Reactive oxygen species Set-point theory Operating point Total peripheral resistance 



Mean arterial pressure


Nucleus tractus solitarii


Reactive oxygen species


Nitric oxide

Ang II

Angiotensin II



Research performed in the Chapleau laboratory related to the topics discussed was supported by funding provided by the NIH (P01 HL14388) and the U.S. Department of Veterans Affairs (1 I01 BX001414) and in the Raven laboratory was supported by funding provided by the NIH (RO-1 grant #s HL045547 and R-21 Grant # HL106431).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Integrative Physiology and AnatomyUniversity of North Texas Health Science CenterFort WorthUSA
  2. 2.Departments of Internal Medicine and Molecular Physiology and BiophysicsUniversity of Iowa and Veterans Affairs Medical CenterIowa CityUSA

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