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European Journal of Applied Physiology

, Volume 113, Issue 10, pp 2613–2619 | Cite as

Influence of CMV/EBV serostatus on respiratory infection incidence during 4 months of winter training in a student cohort of endurance athletes

  • Cheng-Shiun He
  • Michal Handzlik
  • Ayu Muhamad
  • Michael GleesonEmail author
Original Article

Abstract

Aim

The purpose of this study was to examine the influence of previous infection with cytomegalovirus (CMV) or Epstein Barr virus (EBV) on the incidence, severity and duration of upper respiratory tract infections (URTIs) in endurance athletes during a 4-month winter training period.

Methods

Blood samples were obtained from 236 subjects (166 males and 70 females, aged 18–35 years) at the start of the study period. Plasma samples were analysed for CMV and EBV serostatus. Weekly training and daily illness logs were kept for the next 16 weeks.

Results

With regard to CMV/EBV serostatus, the results indicated that athletes with previous CMV infection (n = 58, 25 % of cohort) had significantly fewer URTI symptom days (median 2 vs. 4 days, p = 0.033) during the study period than those with no previous infection (n = 178, 75 %), whereas positive EBV serostatus (n = 197, 84 %) had no influence on URTI episode incidence, severity or duration. Moreover, we found that athletes with prior infection of both CMV and EBV (n = 50, 21 %) had 50 % fewer URTI episodes (p = 0.04) and symptom days (median 2 vs 8 days, p = 0.01) than athletes who were seronegative for both CMV and EBV (n = 31, 13 %).

Conclusions

Previous coinfection with CMV and EBV might promote protective immune surveillance to lower the risk of URTI. Further research is required to clarify why previous CMV and EBV infection reduces the incidence of URTI.

Keywords

Exercise training Herpesvirus T lymphocytes Common cold 

Notes

Acknowledgments

This study was supported by a grant from the Gatorade Sports Science Institute.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Cheng-Shiun He
    • 1
  • Michal Handzlik
    • 2
  • Ayu Muhamad
    • 1
  • Michael Gleeson
    • 1
    Email author
  1. 1.School of Sport, Exercise and Health SciencesLoughborough UniversityLeicestershireUK
  2. 2.School of Biomedical SciencesNottingham UniversityNottinghamUK

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