Effects of aerobic exercise on urinary estrogens and progestagens in pre and postmenopausal women
- 274 Downloads
The purpose of this study was to elucidate the effect of 6 months of aerobic exercise on urinary excretion of female steroid hormones in pre and postmenopausal women and to check the basal values of urinary steroid. To this end, 20 premenopausal (age 45.56 ± 4.06 years) and 20 postmenopausal (age 52.27 ± 3.80 years) women, all sedentary, were studied before and after a supervised 6-month exercise training program (at 60–70% of maximal heart rate, 60 min/day, 3 days/week), based on aerobic dance. The exercise included standing on one leg, squatting, walking, and touching their heels. Before and after the program, anthropometric data and VO2max were measured and urine samples were collected and analyzed by gas chromatography/mass spectrometry (GC/Q-MS). Both, pre and postmenopausal women, improved their VO2max after the aerobic exercise program. Regarding the urinary steroids, on the one hand, important differences were observed between urinary estrogens and progestagens in pre and postmenopausal women in basal values. Estrone (P < 0.05), pregnanediol (P < 0.01), pregnanetriol (P < 0.05), and estriol (P < 0.01) levels were lower in postmenopausal women than in premenopausal women. On the other hand, the aerobic exercise program did not affect postmenopausal women in the same way as premenopausal women. After the exercise program, no changes in urinary steroid levels were observed in premenopausal women. However, the aerobic exercise program caused an increase in urinary excretion of pregnanediol (P < 0.05) and pregnanetriol (P < 0.05) in postmenopausal women.
KeywordsUrinary estrogens Urinary progestagens Menopause Aerobic exercise
This work was supported by the University of Extremadura (Spain) [OR06/A7-07 and A2-37].
Conflict of interest
The authors declare that they have no conflict of interest.
- Brooke-Wavell K, Jones PR, Hardman AE (1997) Brisk walking reduces calcaneal bone loss in post-menopausal women. Clin Sci (Lond) 92:75–80Google Scholar
- Brožek J, Grande F, Anderson JT, Keys A (1963) Densitometric analysis of body composition: revision of some quantitive assumptions. Ann N Y Acad Sci 101:113–140Google Scholar
- Ciolac EG, Bocchi EA, Bortolotto LA, Carvalho VO, Greve JM, Guimarães GV (1998) Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension. Hypertens Res 33(8):836–843CrossRefGoogle Scholar
- De Rose EH, Guimaraes AGS (1980) A model for optimization of somatotype in young athletes. In: M. Ostyn, G. Beunen, J. Simons (Eds) Kinanthropometry II. University Park Press, Baltimore, pp 77–80Google Scholar
- Falk R, Gail M, Fears T, Rossi S, Stanczyk F, Adlercreutz H, Kiura P, Wahala K, Donaldson JL, Vaught J, Fillmore C, Hoover R, Ziegler R (1999) Reproducibility and validity of radioimmunoassays for urinary hormones and metabolites in pre- and postmenopausal women. Cancer Epidemiol Biomarkers Prev 8:C567–C577Google Scholar
- Hughes DC and Runyan SJ (1995) Prenatal care and public policy: lessons for promoting women’s health. J Am Med Womens Assoc 50:156–159, 163Google Scholar
- IUPAC, Analytical chemistry division (1978) Nomenclature, symbol, units and their usage in spectrochemical analysis. II. Data interpretation. Spectrochim Acta B 33:241–246Google Scholar
- Kemmler W, Lauber D, Weineck J, Hensen J, Kalender W, Engelke K (2004) Benefits of 2 years of intense exercise on bone density, physical fitness, and blood lipids in early postmenopausal osteopenic women: results of the Erlangen Fitness Osteoporosis Prevention Study (EFOPS). Arch Intern Med 164:1084–1091PubMedCrossRefGoogle Scholar
- Morris FL, Payne WR, Wark JD (1999a) Prospective decrease in progesterone concentrations in female lightweight rowers during the competition season compared with the off season: a controlled study examining weight loss and intensive exercise. Br J Sports Med 33(6):417–422PubMedCrossRefGoogle Scholar
- Munro CJ, Stabenfeldt GH, Cragun JR, Addiego LA, Overstreet JW, Lasley BL (1991) Relationship of serum estradiol and progesterone concentrations to the excretion profiles of their major urinary metabolites as measured by enzyme immunoassay and radioimmunoassay. Clin Chem 37(6):838–844PubMedGoogle Scholar