Effect of l-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise

  • Shinichi Demura
  • Koji Morishita
  • Takayoshi Yamada
  • Shunsuke Yamaji
  • Miho Komatsu
Original Article


l-Ornithine plays an important role in ammonia metabolism via the urea cycle. This study aimed to examine the effect of l-ornithine hydrochloride ingestion on ammonia metabolism and performance after intermittent maximal anaerobic cycle ergometer exercise. Ten healthy young adults (age, 23.8 ± 3.9 year; height, 172.3 ± 5.5 cm; body mass, 67.7 ± 6.1 kg) with regular training experience ingested l-ornithine hydrochloride (0.1 g/kg, body mass) or placebo after 30 s of maximal cycling exercise. Five sets of the same maximal cycling exercise were conducted 60 min after ingestion, and maximal cycling exercise was conducted after a 15 min rest. The intensity of cycling exercise was based on each subject’s body mass (0.74 N kg−1). Work volume (watt), peak rpm (rpm) before and after intermittent maximal ergometer exercise and the following serum parameters were measured before ingestion, immediately after exercise and 15 min after exercise: ornithine, ammonia, urea, lactic acid and glutamate. Peak rpm was significantly greater with l-ornithine hydrochloride ingestion than with placebo ingestion. Serum ornithine level was significantly greater with l-ornithine hydrochloride ingestion than with placebo ingestion immediately and 15 min after intermittent maximal cycle ergometer exercise. In conclusion, although maximal anaerobic performance may be improved by l-ornithine hydrochloride ingestion before intermittent maximal anaerobic cycle ergometer exercise, the above may not depend on increase of ammonia metabolism with l-ornithine hydrochloride.


l-Ornithine hydrochloride Anaerobic exercise Fatigue recovery Ammonia metabolism 



Authors received financial support from Kyowa Hakko Bio Co., Ltd. No other potential conflict of interest relevant to this article was reported.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Shinichi Demura
    • 1
  • Koji Morishita
    • 2
  • Takayoshi Yamada
    • 3
  • Shunsuke Yamaji
    • 4
  • Miho Komatsu
    • 2
  1. 1.Graduate School of Natural Science and Technology, Kanazawa UniversityKanazawaJapan
  2. 2.Healthcare Products Development Center, Kyowa Hakko Bio Co., Ltd.TsukubaJapan
  3. 3.General Education Center, Fukui National College of TechnologySabaeJapan
  4. 4.Faculty of Medical ScienceUniversity of FukuiYoshidaJapan

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