European Journal of Applied Physiology

, Volume 111, Issue 7, pp 1415–1420

Effects of limb posture on reactive hyperemia

  • Anandi Krishnan
  • Elisabeth B. Lucassen
  • Cindy Hogeman
  • Cheryl Blaha
  • Urs A. Leuenberger
Original Article


To examine the role of limb posture on vascular conductance during rapid changes in vascular transmural pressure, we determined brachial (n = 10) and femoral (n = 10) artery post-occlusive reactive hyperemic blood flow (RHBF, ultrasound/Doppler) and vascular conductance in healthy humans with each limb at three different positions—horizontal, up and down. Limb posture was varied by raising or lowering the arm or leg from the horizontal position by 45°. In both limbs, peak RHBF and vascular conductance were highest in the down or horizontal position and lowest in the up position (arm up 338 ± 38, supine 430 ± 52, down 415 ± 52 ml/min, P < 0.05; leg up 1,208 ± 88, supine 1,579 ± 130, down 1,767 ± 149 ml/min, P < 0.05). In contrast, the maximal dynamic fall in blood flow following peak RHBF (in ml/s/s) in both limbs was highest in the limb-down position and lowest with the limb elevated (P < 0.05). These data suggest that the magnitude and temporal pattern of limb reactive hyperemia is in part related to changes in vascular transmural pressure and independent of systemic blood pressure and sympathetic control.


Blood flow Vascular conductance Arm/leg reactive hyperemia Posture 


  1. Arima S, Ito S (2003) The mechanisms underlying altered vascular resistance of glomerular afferent and efferent arterioles in diabetic nephropathy. Nephrol Dial Transplant 18:1966–1969PubMedCrossRefGoogle Scholar
  2. Bayliss WM (1902) On the local reactions of the arterial wall to changes of internal pressure. J Physiol (London) 28:220–231Google Scholar
  3. Carlsson I, Sollevi I, Wennmalm A (1987) The role of myogenic relaxation, adenosine and prostaglandins in human forearm reactive hyperemia. J Physiol (London) 389:147–161Google Scholar
  4. Cipolla MJ, McCall AL, Lessov N, Porter JM (1997) Reperfusion decreases myogenic reactivity and alters middle cerebral artery function after focal cerebral ischemia in rats. Stroke 28:176–180PubMedGoogle Scholar
  5. Davis MJ, Hill MA (1999) Signaling mechanisms underlying the vascular myogenic response. Physiol Rev 79:387–423PubMedGoogle Scholar
  6. Durand S, Zhang R, Cui J, Wilson TE, Crandall CG (2004) Evidence of a myogenic response in vasomotor control of forearm and palm cutaneous microcirculations. J Appl Physiol 97:535–539PubMedCrossRefGoogle Scholar
  7. Feihl F, Liaudet L, Waeber B, Levy BI (2006) Hypertension: a disease of the microcirculation? Hypertension 48:1012–1017PubMedCrossRefGoogle Scholar
  8. Henriksen O (1991) Sympathetic reflex control of blood flow in human peripheral tissues. Acta Physiol Scand 603:33–39Google Scholar
  9. Imadojemu VI, Lott MEJ, Gleeson K, Hogeman CS, Ray CA, Sinoway LI (2001) Contribution of perfusion pressure to vascular resistance response during head-up tilt. Am J Physiol Heart Circ Physiol 281:H371–H375PubMedGoogle Scholar
  10. Izzard AS, Bund SJ, Heagerty AM (1996) Myogenic tone in mesenteric arteries from spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 270:H1–H6Google Scholar
  11. Jepsen H, Gaehtgens P (1995) Postural vascular response vs sympathetic vasoconstriction in human skin during orthostasis. Am J Physiol Heart Circ Physiol 269:H53–H61Google Scholar
  12. Johnson PC (1959) Myogenic nature of increase in intestinal vascular resistance with venous pressure elevation. Circ Res 7:992–999PubMedGoogle Scholar
  13. Johnson PC (1980) The myogenic response. In: Bohr DF, Somlyo AP, Sparks HV Jr, Geiger SR (eds) Handbook of physiology—the cardiovascular system: vascular smooth muscle, section 2, vol 2. American Physiological Society, Bethesda, pp 409–442Google Scholar
  14. Johnson PC (1986) Autoregulation of blood flow. Circ Res 59:483–495PubMedGoogle Scholar
  15. Kooijman M, de Hoog M, Rongen GA, van Kuppevelt HJ, Smits P, Hopman MT (2007) Local vasoconstriction in spinal cord-injured and able-bodied individuals. J Appl Physiol 103:1070–1077PubMedCrossRefGoogle Scholar
  16. Lenders J, Janssen G-J, Smits P, Thien T (1991) Role of the wrist cuff in forearm plethysmography. Clin Sci 80:413–417PubMedGoogle Scholar
  17. Levick JR, Michel CC (1978) The effects of position and skin temperature on the capillary pressures in the fingers and toes. J Physiol 274:97–109PubMedGoogle Scholar
  18. Lott MEJ, Herr MD, Sinoway LI (2002) Effects of transmural pressure on brachial artery mean blood flow velocity dynamics in humans. J Appl Physiol 93:2137–2146PubMedGoogle Scholar
  19. Lott ME, Herr MD, Sinoway LI (2004) Effects of age on brachial artery myogenic responses in humans. Am J Physiol Regul Integr Comp Physiol 287:R586–R591PubMedCrossRefGoogle Scholar
  20. Lott M, Hogeman C, Herr M, Huang K, Sinoway L (2005) Comparison of brachial and femoral artery myogenic responses in young subjects. Med Sci Sports Exerc 37:S224 AbstractCrossRefGoogle Scholar
  21. Matrougui K, Schiavi P, Guez D, Henrion D (1998) High sodium intake decreases pressure-induced (myogenic) tone and flow-induced dilation in resistance arteries from hypertensive rats. Hypertension 32:176–179PubMedGoogle Scholar
  22. McDaniel J, Fjeldstad AS, Ives S, Hayman M, Kithas P, Richardson RS (2010) Central and peripheral contributors to skeletal muscle hyperemia: response to passive limb movement. J Appl Physiol 108:76–84PubMedCrossRefGoogle Scholar
  23. Mohrman DE, Sparks HV (1974) Myogenic hyperemia following brief tetanus of canine skeletal muscle. Am J Physiol 227:531–535PubMedGoogle Scholar
  24. Muller JM, Davis MJ, Chilian WM (1996) Integrated regulation of pressure and flow in the coronary microcirculation. Cardiovasc Res 32:668–678PubMedGoogle Scholar
  25. Newcomer SC, Leuenberger UA, Hogeman CS, Handly BD, Proctor DN (2004) Different vasodilator responses of human arms and legs. J Physiol (London) 556:1001–1011CrossRefGoogle Scholar
  26. Newcomer SC, Leuenberger UA, Hogeman CS, Proctor DN (2005) Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance training. Am J Physiol Heart Circ Physiol 289:H308–H315PubMedCrossRefGoogle Scholar
  27. Nurkiewicz TR, Boegehold MA (1998) High dietary salt alters arteriolar myogenic responsiveness in normotensive and hypertensive rats. Am J Physiol Heart Circ Physiol 275:H2095–H2104Google Scholar
  28. Okazaki K, Fu Q, Martini ER, Shook R, Conner C, Zhang R, Crandall CG, Levine BD (2005) Vasoconstriction during venous congestion: effects of venoarteriolar response, myogenic reflexes, and hemodynamics of changing perfusion pressure. Am J Physiol Regul Integr Comp Physiol 289:R1354–R1359PubMedCrossRefGoogle Scholar
  29. Patterson GC, Whelan RF (1955) Reactive hyperaemia in the human forearm. Clin Sci 14:197–209PubMedGoogle Scholar
  30. Rowell LB (1986) Human circulation. Regulation during physical stress. Oxford University Press, New YorkGoogle Scholar
  31. Schubert R, Mulvany MJ (1999) The myogenic response: established facts and attractive hypotheses. Clin Sci 96:313–326PubMedCrossRefGoogle Scholar
  32. Secher NH, Volianitis S (2006) Are the arms and legs in competition for cardiac output? Med Sci Sports Exerc 38:1797–1803PubMedCrossRefGoogle Scholar
  33. Taylor JA, Hand GA, Johnson DG, Seals DR (1992) Augmented forearm vasoconstriction during dynamic exercise in healthy older men. Circulation 86:1789–1799PubMedGoogle Scholar
  34. Taylor JA, Halliwill JR, Brown TE, Hayano J, Eckberg DL (1995) ‘Non-hypotensive’ hypovolemia reduces ascending aortic dimensions in humans. J Physiol (London) 483:289–298Google Scholar
  35. Veerareddy S, Cooke CL, Baker PN, Davidge ST (2002) Vascular adaptations to pregnancy in mice: effects on myogenic tone. Am J Physiol Heart Circ Physiol 283:H2226–H2233PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Anandi Krishnan
    • 1
  • Elisabeth B. Lucassen
    • 1
  • Cindy Hogeman
    • 1
  • Cheryl Blaha
    • 1
  • Urs A. Leuenberger
    • 1
  1. 1.Penn State Heart and Vascular Institute, H047, Milton S. Hershey Medical CenterPennsylvania State University College of MedicineHersheyUSA

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