European Journal of Applied Physiology

, Volume 109, Issue 2, pp 201–211 | Cite as

Low vagal tone is associated with impaired post stress recovery of cardiovascular, endocrine, and immune markers

  • Cora Stefanie Weber
  • Julian F. Thayer
  • Miriam Rudat
  • Petra H. Wirtz
  • Frank Zimmermann-Viehoff
  • Alexander Thomas
  • Frank H. Perschel
  • Petra C. Arck
  • Hans C. Deter
Original Article

Abstract

Reduced heart rate variability (HRV) and delayed blood pressure recovery are associated with increased cardiovascular risk. Besides this evident link, the vagus is thought to play an inhibitory role in the regulation of other allostatic systems, including inflammation and the hypothalamic–pituitary–adrenal (HPA) axis. However, human evidence is scarce. To further explore these associations and with special regard to the postulated mediating role of the vagus, we hypothesised that subjects with low vagal tone as indexed by reduced resting HRV would show impaired post-stress recovery of cardiovascular, endocrine and immune system markers involved in cardiovascular pathology. 44 healthy men underwent a standardised mental stress test. Besides continuous measurement of systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), and HRV serum cortisol, tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were measured before, after, 20, and 60 min after stress. Low versus high HRV groups was defined by median split on resting HRV (RMSSD). The task elicited significant time effects for SBP, DBP, HR, HRV, cortisol, and TNF-alpha. Subjects with low baseline HRV showed almost no modulation of HRV coupled with overall reduced HRV levels, and impaired recovery of DBP, cortisol, and TNF-alpha. Confirming our hypothesis, low vagal tone was associated with impaired recovery of cardiovascular, endocrine, and immune markers in healthy males. The data support an inhibitory role of the vagus in the regulation of allostatic systems as described in the neurovisceral integration model. We posit reduced resting HRV as a risk marker for future cardiovascular and other stress-related disease.

Keywords

Heart rate variability Stress Recovery Blood pressure Cortisol TNF-alpha 

Notes

Acknowledgments

The authors would like to thank the healthy volunteers for participating in the study and Baerbel Girresch for her help with the biochemical analyses. The study was supported by the Universitäre Forschungsförderung of the Charité (Charité University funding, project no. 2006-874).

Conflict of interest statement

There are no financial or other relationships that would lead to a conflict of interest.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Cora Stefanie Weber
    • 1
  • Julian F. Thayer
    • 2
    • 3
  • Miriam Rudat
    • 1
  • Petra H. Wirtz
    • 4
  • Frank Zimmermann-Viehoff
    • 1
  • Alexander Thomas
    • 1
  • Frank H. Perschel
    • 5
  • Petra C. Arck
    • 6
  • Hans C. Deter
    • 1
  1. 1.Department of Psychosomatic Medicine and PsychotherapyCharité UniversitätsmedizinBerlinGermany
  2. 2.Department of PsychologyOhio State UniversityColumbusUSA
  3. 3.Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical FacultyHeidelberg UniversityMannheimGermany
  4. 4.Clinical Psychology and PsychotherapyUniversity of ZurichZurichSwitzerland
  5. 5.Central Institute of Laboratory Medicine and PathobiochemistryCharité UniversitätsmedizinBerlinGermany
  6. 6.Laboratory for Psychoneuroimmunological ResearchCharité UniversitätsmedizinBerlinGermany

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