This study compared the first and second exercise bouts consisting of electrically evoked isometric contractions for muscle damage profile. Nine healthy men (31 ± 4 years) had two electrical muscle stimulation (EMS) bouts separated by 2 weeks. The knee extensors of one leg were stimulated by biphasic rectangular pulses (75 Hz, 400 μs, on–off ratio 5–15 s) at the knee joint angle of 100° (0°, full extension) to induce 40 isometric contractions, while the current amplitude was increased to maintain maximal force generation. Maximal voluntary isometric contraction (MVC) torque of the knee extensors at 100°, muscle soreness, pressure pain threshold and plasma creatine kinase (CK) activity were used as indirect markers of muscle damage, and measured before and 1, 24, 48, 72 and 96 h after EMS bout, and the changes over time were compared between bouts. The torque produced during exercise was approximately 30% of MVC, and no significant difference between bouts was evident for the changes in peak and average torque over 40 contractions. MVC decreased significantly (P < 0.05) by 26% immediately and 1 h after both bouts, but the recovery was significantly (P < 0.05) faster after the second bout (100% at 96 h) compared with the first bout (81% at 96 h). Development of muscle soreness and tenderness, and increases in plasma CK activity were significantly (P < 0.05) smaller after the second than the first bout. These results show that changes in muscle damage markers were attenuated in the second EMS bout compared with the initial EMS bout.
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Adams GR, Harris RT, Woodard D, Dudley GA (1993) Mapping of electrical muscle stimulation using MRI. J Appl Physiol 74:532–537
Balogun JA, Balogun JA, Onilari OO, Akeju OA, Marzouk DK (1993) High voltage electrical stimulation in the augmentation of muscle strength: effects of pulse frequency. Arch Phys Med Rehabil 74:910–916
Black CD, McCully KK (2008) Muscle injury after repeated bouts of voluntary and electrically stimulated exercise. Med Sci Sports Exerc 40:1605–1615
Brown SJ, Child RB, Day SH, Donnelly AE (1997) Exercise-induced skeletal muscle damage and adaptation following repeated bouts of eccentric muscle contractions. J Sports Sci 15:215–222
Butterfield DL, Draper DO, Ricard MD, Myrer JW, Schulthies SS, Durrant E (1997) The effects of high-volt pulsed current electrical stimulation on delayed-onset muscle soreness. J Athl Train 32:15–20
Collins DF (2007) Central contributions to contractions evoked by tetanic neuromuscular electrical stimulation. Exerc Sport Sci Rev 35:102–109
Day ML, McGuigan MR, Brice G, Foster C (2004) Monitoring exercise intensity during resistance training using the session RPE scale. J Strength Cond Res 18:353–358
Eriksson E, Haggmark T (1979) Comparison of isometric muscle training and electrical stimulation supplementing isometric muscle training in the recovery after major knee ligament surgery: a preliminary report. Am J Sports Med 7:169–171
Gibson JN, Morrison WL, Scrimgeour CM, Smith K, Stoward PJ, Rennie MJ (1989) Effects of therapeutic percutaneous electrical stimulation of atrophic human quadriceps on muscle composition, protein synthesis and contractile properties. Eur J Clin Invest 19:206–212
Gondin J, Guette M, Ballay Y, Martin A (2005) Electromyostimulation training effects on neural drive and muscle architecture. Med Sci Sports Exerc 37:1291–1299
Gregory CM, Bickel CS (2005) Recruitment patterns in human skeletal muscle during electrical stimulation. Phys Ther 85:358–364
Hainaut K, Duchateau J (1992) Neuromuscular electrical stimulation and voluntary exercise. Sports Med 14:100–113
Hansen M, Trappe T, Crameri RM, Qvortrup K, Kjaer M, Langberg H (2009) Myofibrillar proteolysis in response to voluntary or electrically stimulated muscle contractions in humans. Scand J Med Sci Sports 19:75–82
Ingalls CP, Wenke JC, Nofal T, Armstrong RB (2004) Adaptation to lengthening contraction-induced injury in mouse muscle. J Appl Physiol 97:1067–1076
Jones DA, Newham DJ, Torgan C (1989) Mechanical influences on long-lasting human muscle fatigue and delayed-onset pain. J Physiol 412:415–427
Jubeau M, Sartorio A, Marinone PG, Agosti F, Van Hoecke J, Nosaka K, Maffiuletti NA (2008) Comparison between voluntary and stimulated contractions of the quadriceps femoris for growth hormone response and muscle damage. J Appl Physiol 104:75–81
Kim CK, Bangsbo J, Strange S, Karpakka J, Saltin B (1995a) Metabolic response and muscle glycogen depletion pattern during prolonged electrically induced dynamic exercise in man. Scand J Rehabil Med 27:51–58
Kim CK, Takala TE, Seger J, Karpakka J (1995b) Training effects of electrically induced dynamic contractions in human quadriceps muscle. Aviat Space Environ Med 66:251–255
Lake DA (1992) Neuromuscular electrical stimulation: an overview and its application in the treatment of sports injuries. Sports Med 13:320–336
Lyons CL, Robb JB, Irrgang JJ, Fitzgerald GK (2005) Differences in quadriceps femoris muscle torque when using a clinical electrical stimulator versus a portable electrical stimulator. Phys Ther 85:44–51
Mackey AL, Bojsen-Moller J, Qvortrup K, Langberg H, Suetta C, Kalliokoski KK, Kjaer M, Magnusson SP (2008) Evidence of skeletal muscle damage following electrically stimulated isometric muscle contractions in humans. J Appl Physiol 105:1620–1627
Maffiuletti NA, Dugnani S, Folz M, Di Pierno E, Mauro F (2002) Effect of combined electrostimulation and plyometric training on vertical jump height. Med Sci Sports Exerc 34:1638–1644
Mair J, Mayr M, Muller E, Koller A, Haid C, Artner-Dworzak E, Calzolari C, Larue C, Puschendorf B (1995) Rapid adaptation to eccentric exercise-induced muscle damage. Int J Sports Med 16:352–356
Malatesta D, Cattaneo F, Dugnani S, Maffiuletti NA (2003) Effects of electromyostimulation training and volleyball practice on jumping ability. J Strength Cond Res 17:573–579
McHugh MP, Connolly DA, Eston RG, Gleim GW (1999) Exercise-induced muscle damage and potential mechanisms for the repeated bout effect. Sports Med 27:157–170
Newham DJ, Jones DA, Clarkson PM (1987) Repeated high-force eccentric exercise: effects on muscle pain and damage. J Appl Physiol 63:1381–1386
Nosaka K, Clarkson PM (1995) Muscle damage following repeated bouts of high force eccentric exercise. Med Sci Sports Exerc 27:1263–1269
Nosaka K, Sakamoto K, Newton M, Sacco P (2001) The repeated bout effect of reduced-load eccentric exercise on elbow flexor muscle damage. Eur J Appl Physiol 85:34–40
Nosaka K, Newton M, Sacco P (2002) Responses of human elbow flexor muscles to electrically stimulated forced lengthening exercise. Acta Physiol Scand 174:137–145
Nosaka K, Muthalib M, Lavender A, Laursen PB (2007) Attenuation of muscle damage by preconditioning with muscle hyperthermia 1-day prior to eccentric exercise. Eur J Appl Physiol 99:183–192
Robertson V, Ward AR, Low J, Reed A (2006) Electrotherapy explained: principles and practice. Butterworth-Heinemann Ltd, London
Saxton JM, Donnelly AE (1996) Length-specific impairment of skeletal muscle contractile function after eccentric muscle actions in man. Clin Sci (Lond) 90:119–125
Smith GV, Alon G, Roys SR, Gullapalli RP (2003) Functional MRI determination of a dose–response relationship to lower extremity neuromuscular electrical stimulation in healthy subjects. Exp Brain Res 150:33–39
Ward AR, Robertson VJ (1998) Sensory, motor, and pain thresholds for stimulation with medium frequency alternating current. Arch Phys Med Rehabil 79:273–278
Warren GL, Lowe DA, Armstrong RB (1999) Measurement tools used in the study of eccentric contraction-induced injury. Sports Med 27:43–59
Zorn C, Szekeres T, Keilani M, Fialka-Moser V, Crevenna R (2007) Effects of neuromuscular electrical stimulation of the knee extensor muscles on muscle soreness and different serum parameters in young male athletes: preliminary data. Br J Sports Med 41:914–916
Zory R, Boerio D, Jubeau M, Maffiuletti NA (2005) Central and peripheral fatigue of the knee extensor muscles induced by electromyostimulation. Int J Sports Med 26:847–853
The authors thank the subjects for participating in this study and Mr Mark Muthalib for his help in analyzing the data.
Communicated by Roberto Bottinelli.
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Aldayel, A., Jubeau, M., McGuigan, M.R. et al. Less indication of muscle damage in the second than initial electrical muscle stimulation bout consisting of isometric contractions of the knee extensors. Eur J Appl Physiol 108, 709–717 (2010). https://doi.org/10.1007/s00421-009-1278-0
- Maximal voluntary contraction
- Creatine kinase
- Muscle soreness
- Pressure pain threshold
- Repeated bout effect