Do sessions of cryostimulation have influence on white blood cell count, level of IL6 and total oxidative and antioxidative status in healthy men?
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The influence of extremely low temperatures on the human body and physiological reactions are not fully recognized. It has been postulated that cryostimulation could modify immunological reactions, leukocytes mobilization and levels of cytokines. The aim of this research was to estimate the influence of a ten sessions 3-min-long exposures to cryogenic temperature (−130°C) on the white blood cell (WBC) count, level of IL6 and the total oxidative and antioxidative status in 15 young, clinically healthy men. Blood samples were obtained in the morning before cryostimulation, again 30 min after treatment and the next day in the morning, both during the first and tenth session. The WBC count, level of IL6 and total lipid peroxides as the total oxidative status and the total antioxidative status (TAS), were measured. After completing a total of ten whole-body therapy sessions a significant increase in WBC count, especially lymphocytes and monocytes was noted. There was an increase in level of IL6 after first and the last cryostimulation the most pronounced after tenth session. On the contrary the TAS level decreased significant after the treatment. It was concluded that repeated expositions to extremely low temperatures use in cryostimulation have mobilization effect on immunological system.
KeywordsCryostimulation White blood cell count Interleukin-6 Total oxidative and antioxidative capacity
This paper was supported by the Ministry of Science and Higher Education, Grant no N N404 027235. We are very grateful to Ms. Danuta Charland for correcting the English grammar and style of the final version of the manuscript.
- Banfi G, Krajewska M, Melegati G, Patacchini M (2008) Effects of whole-body cryotherapy on haematological values in athletes. Br J Sports Med 42:558–559Google Scholar
- Blatteis CM (1998) Physiology and pathophysiology of temperature regulation. World Scientific, SingaporeGoogle Scholar
- Chudecka M, Lubkowska A, Klimek A, Szygula Z (2008) The impact of systemic cryotherapy on distribution and the dynamics of temperature changes in the selected parts of body. Acta Bio Opt Inform Med 1(14):103–106Google Scholar
- Jackowska E, Pisula A, Drulis-Kawa Z, Guz K, Bugla-Plokonska G, Doroszkiewicz W, Strek W (2006) Changes of level of immunoglobulins and C3 and C4 proteins in serum during whole body cryotherapy. Acta Bio Opt Inform Med 2(12):101–103Google Scholar
- Korzonek-Szlacheta I, Wielkoszynski T, Stanek A, Swietochowska E, Karpe J, Sieron A (2007) Influence of whole body cryotherapy on the levels of some hormones in professional footballers. Pol J Endocrinol 58(1):27–32Google Scholar
- Leppäluoto J, Westerlund T, Huttunen P, Oksa J, Smolander J, Dugué B, Mikkelsson M (2008) Effects of long-term whole-body cold exposures on plasma concentrations of ACTH, beta-endorphin, cortisol, catecholamines and cytokines in healthy females. Scand J Clin Lab Invest 68:145–153CrossRefPubMedGoogle Scholar
- Rhind SG, Castellani JW, Brenner IKM, Shephard RJ, Zamecnik J, Montain SJ, Young AJ, Shek PN (2001) Intracellular monocyte and serum cytokine expression is modulated by exhausting exercise and cold exposure. Am J Physiol Regul Integr Comp Physiol 291:R66–R75Google Scholar
- Siems WG, Brenke R, Sommerburg O, Grune T (1999) Improved antioxidative protection in winter swimmers. Q J Med 92:193–198Google Scholar
- Stanek A, Cieslar G, Rosmus-Kuczia I, Matyszkiewicz B, Romuk E, Skrzep-Poloczek B, Birkner E, Sieroń A (2006) Influence of whole body cryotherapy on blood morphology parameters in patients with ankylosing spondylitis and in healthy volunteers. Acta Bio Opt Inform Med 12(3):207–210Google Scholar
- Stanek A, Cieslar G, Sieron A (2007) Therapeutic application of cryotherapy in clinical practice. Baln Pol 107:37–45Google Scholar
- Steensberg A, Fischer CP, Keller C, Møller K, Pedersen BK (2003) IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Endocrinol Metab 285:433–437Google Scholar