Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study

  • Richard D. SembaEmail author
  • Stefania Bandinelli
  • Kai Sun
  • Jack M. Guralnik
  • Luigi Ferrucci
Short Communication


Advanced glycation end products (AGEs) are bioactive molecules found in foods and generated endogenously in the body. AGEs induce cross-linking of collagen and increase the stiffness of skeletal muscle and cartilage. We characterized the relationship between a plasma AGE, carboxymethyl-lysine (CML), and slow walking speed (lowest quintile of walking speed) in older adults. Walking speed over a 4 m course was assessed in 944 adults, aged ≥65 years, in the InCHIANTI study, a population-based study of aging and mobility disability conducted in two towns in Tuscany, Italy. Participants in the highest quartile of plasma CML were at higher risk of slow walking speed (Odds Ratio [O.R.] 1.56, 95% Confidence Interval [C.I.] 1.02–2.38, P = 0.04) compared to those in the lower three quartiles of plasma CML in a logistic regression models adjusting for age, education, cognitive function, smoking, and chronic diseases. After exclusion of participants with diabetes, participants in the highest quartile of plasma CML were at higher risk of slow walking speed (O.R. 1.87, 95% C.I. 1.15–3.04, P = 0.01) adjusting for the same covariates. In older community-dwelling adults, elevated plasma CML is independently associated with slow walking speed.


Advanced glycation end products Aging Carboxymethyl-lysine Physical performance Walking speed 



This work was supported by National Institute on Aging Grant R01 AG027012, R56 AG027012, R01 AG029148 and the Intramural Research Program, National Institute on Aging, NIH.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Richard D. Semba
    • 1
    Email author
  • Stefania Bandinelli
    • 2
  • Kai Sun
    • 1
  • Jack M. Guralnik
    • 3
  • Luigi Ferrucci
    • 4
  1. 1.Department of OphthalmologyJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Azienda Sanitaria FirenzeFlorenceItaly
  3. 3.Laboratory of Epidemiology, Demography, and BiometryNational Institute on AgingBethesdaUSA
  4. 4.Longitudinal Studies Section, Clinical Research BranchNational Institute on AgingBaltimoreUSA

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