Effect of prior exercise on postprandial lipemia and markers of inflammation and endothelial activation in normal weight and overweight adolescent boys

  • Owen J. MacEneaney
  • Michael Harrison
  • Donal J. O’Gorman
  • Elena V. Pankratieva
  • Paul L. O’Connor
  • Niall M. Moyna
Original Article

Abstract

Postprandial lipemia (PPL) is associated with impaired endothelial function and inflammation. Acute exercise reduces PPL in adults. This investigation examined the effect of an acute bout of exercise on postprandial changes in triglycerides (TG), glucose, insulin, inflammation [white blood cell count (WBC), interleukin-6 (IL-6) tumor necrosis factor-alpha, C-reactive protein (CRP)] and endothelial activation [soluble intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1)] following a high-fat meal in adolescents. Ten normal weight (NW) (BMI, 20.9 ± 1.7 kg m−2; 15.6 ± 0.7 years) and eight overweight (OW) (BMI, 28.3 ± 3.6 kg m−2; 15.9 ± 0.4 years) adolescent boys underwent two 6-h oral fat tolerance tests (OFTT) separated by 7–10 days. On the evening prior to each OFTT, subjects either rested or completed a treadmill exercise bout (65% \( \dot{V}{\text{O}}_{2\max } ; \) 600 kcal expended). Exercise reduced (P < 0.01) the postprandial TG area under the curve by ~20% in the NW and OW groups. The postprandial glucose and insulin response did not differ between the control and exercise trials or between the NW and OW groups. Circulating leukocytes and plasma IL-6 levels increased (P < 0.01) in the NW and OW groups 6 h following the OFTT in both experimental conditions. There were no changes in CRP, sVCAM-1 or sICAM-1 following the OFTT and there were no differences between experimental condition or NW and OW groups. In conclusion, a moderate exercise bout prior to a high-fat meal effectively reduces postprandial TG concentrations to a similar degree in both NW and OW adolescents, but does not reduce the concomitant postprandial increase in WBC or IL-6.

Keywords

Exercise Adolescents Postprandial lipemia Triglycerides Inflammation IL-6 Leukocytes ICAM-1 VCAM-1 

Notes

Acknowledgments

We would like to thank all of the subjects who participated in the study as well as Martin Duggan, Willie Guerin, John Horan, Colm Keogh, Dermot Morris, and Brian Talty for their invaluable assistance. This study was supported by The Irish Research Council for Science, Engineering and Technology and the EMBARK Initiative, funded by the National Development Plan.

Conflict of interest statement

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Owen J. MacEneaney
    • 1
    • 3
  • Michael Harrison
    • 2
  • Donal J. O’Gorman
    • 1
  • Elena V. Pankratieva
    • 1
  • Paul L. O’Connor
    • 1
  • Niall M. Moyna
    • 1
  1. 1.Dublin City UniversityDublin 9Ireland
  2. 2.Waterford Institute of TechnologyWaterfordIreland
  3. 3.Integrative Vascular Biology Laboratory, Department of Integrative PhysiologyUniversity of ColoradoBoulderUSA

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