European Journal of Applied Physiology

, Volume 106, Issue 5, pp 713–720 | Cite as

Effects of acute hypoxia tests on blood markers in high-level endurance athletes

  • Rémi Mounier
  • Vincent Pialoux
  • Laurent Schmitt
  • Jean-Paul Richalet
  • Paul Robach
  • Jean Coudert
  • Eric Clottes
  • Nicole FellmannEmail author
Original Article


The aim of this study was to determine the response of blood markers to acute hypoxia in high-level endurance athletes before training based on “living high-training low” model. Thirty endurance athletes performed a hypoxic cycling test and spent 3 h at rest in a simulated altitude of 3,000 m. At the end of the hypoxic cycling test, the quantity of the natural antisense transcript of HIF-1α mRNA (aHIF) transcript increased significantly (+37%, P = 0.024). After 3-h exposure, at a simulated altitude of 3,000 m, the amount of HIF-1α mRNA increased significantly (+57%, P = 0.012). Moreover, a large inter-subject range was observed in response to the hypoxic cycling test and to the prolonged hypoxic exposure: −133%/+79% and −82%/+653% for HIF-1α mRNA, 69%/+324% and −76%/+229% for aHIF. This study shows a large inter-variability of blood markers in elite athletes in response to acute hypoxic exposure corroborating previous observations made in other populations.


HIF-1α Natural antisense of HIF-1α Leukocyte 



This study was funded by the “International Olympic Committee” and the “Ministère de la Jeunesse et des Sports”. The authors would like to thank the athletes for their donation of time and blood. We also thank Fabrice Kwiatkowski for statistics and Glen Foster for careful reading of the manuscript.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Rémi Mounier
    • 1
  • Vincent Pialoux
    • 1
  • Laurent Schmitt
    • 2
  • Jean-Paul Richalet
    • 3
  • Paul Robach
    • 4
  • Jean Coudert
    • 1
  • Eric Clottes
    • 1
    • 5
  • Nicole Fellmann
    • 1
    Email author
  1. 1.Laboratoire de Biologie des Activités Physiques et SportivesFaculté de MédecineClermont-FerrandFrance
  2. 2.Centre National de Ski Nordique, ID JacobeysPrémanonFrance
  3. 3.Laboratoire «Réponses Cellulaires et Fonctionnelles à l’Hypoxie», EA 2363, ARPEUniversité Paris 13BobignyFrance
  4. 4.Ecole Nationale de Ski et d’AlpinismeChamonixFrance
  5. 5.Institut de Pharmacologie et de Biologie StructuraleToulouseFrance

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