Here, we investigated the effect of jump exercise on tumor growth, cancer cachexia, lymphocyte proliferation and macrophage function in Walker 256 tumor-bearing rats. Male Wistar rats (60 days) were divided into sedentary (C) and exercised (E) groups. Jump training consisted of six sets of 10 jumps in water with overload of 50% of body mass with 1 min of resting, four times per week for 8 weeks. After 6 weeks of training, half of each group was inoculated with 2 × 107 cells of Walker 256 tumor. Sedentary tumor-bearing and exercised tumor-bearing are referred to as T and TE, respectively. Tumor weight in the T group was 25 g. These animals display loss of weight, hypertriacylglycerolemia, hyperlacticidemia, depletion of glycogen stores and increase in PIF expression. Jump exercise (TE) induced a significant lower tumor weight, preserves liver glycogen stores, partly prevented the hypertriacylglycerolemia, hyperlacticidemia and, prevented the fall in body weight and reduced PIF expression. Lymphocyte was increased by tumor burden (T) and was higher by including exercise (TE). The same was observed regarding phagocytosis and lysosomal volume. Anaerobic exercise decreases tumor growth, cancer cachexia and increases innate and adaptative immune function.
Cancer Exercise Cachexia Macrophage Lymphocyte Immune system
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Argilés JM, Busquets S, Garcia-Martinez C et al (2005) Mediators involved in the cancer anorexia-cachexia syndrome: past, present and future. Nutrition 21:977–985PubMedGoogle Scholar
Bacurau AV, Belmonte MA, Navarro F et al (2007) Effect of a high-intensity exercise on the metabolism and function of macrophages and lymphocytes of Walker 256 tumor-bearing rats. Exp Biol Med 232:1289–1299. doi:10.3181/0704-RM-93CrossRefGoogle Scholar
Baar K, Esser K (1999) Phosphorylation of p70(S6 k) correlates with increased skeletal muscle mass following resistance exercise. Am J Physiol 276:C120–C127PubMedGoogle Scholar
Engle PC, Jones JB (1978) Causes and elimination of erratic blanks in enzymatic metabolite assays involving the use of NAD in alkaline hydrazine buffers: improved conditions of l-glutamate, l-lactate and other metabolites. Anal Biochem 88:475–484. doi:10.1016/0003-2697(78)90447-5CrossRefGoogle Scholar
Schrey MP, Patel KV (1995) Prostaglandin E production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators. Br J Cancer 72:1412–1419PubMedGoogle Scholar
Wigmore SJ, Fearon KCH, Sangster K et al (2002) Cytokine regulation of constitutive production of interleukin-8 and 6 by human pancreatic cancer cell lines and serum cytokine concentration in patients with pancreatic cancer. Int J Oncol 21:881–886PubMedGoogle Scholar