European Journal of Applied Physiology

, Volume 103, Issue 5, pp 539–543 | Cite as

Changes in central artery blood pressure and wave reflection during a cold pressor test in young adults

  • Darren P. CaseyEmail author
  • Randy W. Braith
  • Gary L. Pierce
Original Article


The relative contribution of sympathetic nervous system (SNS)-induced increase in peripheral vascular resistance on central artery blood pressure (BP) and aortic wave reflection (augmentation index; AIx) is not completely understood. Central BP and wave reflection characteristics were measured using radial artery applanation tonometry before, during a 3-min cold pressor test (CPT), and 90 and 180-s post-CPT in 15 young, healthy adults (25 ± 1 years). The CPT resulted in a greater magnitude of change in the estimated aortic systolic (31 vs. 23%, P < 0.05) and pulse (31 vs. 13%, P < 0.05) BP compared with the change in brachial artery BP. Additionally, the CPT resulted in an increased mean arterial pressure (MAP) (< 0.05) and AIx (10 ± 2 vs. 26 ± 2%, P < 0.05). The change in MAP during the CPT was correlated to the change in AIx (r = 0.73, P < 0.01) and inversely related to roundtrip duration of the reflected wave to the periphery and back (r = –0.57, < 0.05). The present study suggests that cold pressor testing results in a significant increase in arterial wave reflection intensity, possibly due to an increased MAP. However, the greater increase in systolic and pulse BP in the central compared with the peripheral circulation suggests that increased central artery wave reflection intensity contributes to increased left ventricular myocardial oxygen demand during CPT-induced hypertension.


Wave reflection Blood pressure Sympathetic nervous system 


Conflict of interest

There are no conflicts of interest to disclose.


  1. Casey DP, Pierce GL, Nichols WW, Braith RW (2006) Measurement of pulse wave velocity and augmentation index is reproducible in young, healthy men (abstract). Med Sci Sport Exer 38:S185–S186Google Scholar
  2. Chen CH, Nevo E, Fetics B, Pak PH, Yin FC, Maughan WL, Kass DA (1997) Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure: validation of generalized transfer function. Circulation 95:1827–1836PubMedGoogle Scholar
  3. Dinenno FA, Tanaka H, Stauffer BL, Seals DR (2001) Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction. J Physiol 536:977–983PubMedCrossRefGoogle Scholar
  4. Dishman RK, Nakamura Y, Jackson EM, Ray CA (2003) Blood pressure and muscle sympathetic nerve activity during cold pressor stress: fitness and gender. Psychophysiology 40:370–380PubMedCrossRefGoogle Scholar
  5. Edwards DG, Gauthier AL, Hayman MA, Lang JT, Kenefick RW (2006) Acute effects of cold exposure on central aortic wave reflection. J Appl Physiol 100:1210–1214PubMedCrossRefGoogle Scholar
  6. Esler M (2000) The sympathetic system and hypertension. Am J Hypertens 13:99S–105SPubMedCrossRefGoogle Scholar
  7. Gallagher D, Adji A, O’Rourke MF (2004) Validation of the transfer function technique for generating central from peripheral upper limb pressure waveform. Am J Hypertens 17:1059–1067PubMedCrossRefGoogle Scholar
  8. Geleris P, Stavrati A, Boudoulas H (2004) Effect of cold, isometric exercise, and combination of both on aortic pulse in healthy subjects. Am J Cardiol 93:265–267PubMedCrossRefGoogle Scholar
  9. Koch DW, Leuenberger UA, Proctor DN (2003) Augmented leg vasoconstriction in dynamically exercising older men during acute sympathetic stimulation. J Physiol 551:337–344PubMedCrossRefGoogle Scholar
  10. Lambert EA, Schlaich MP (2004) Reduced sympathoneural responses to the cold pressor test in individuals with essential hypertension and in those genetically predisposed to hypertension: no support for the “pressor reactor” hypothesis of hypertension development. Am J Hypertens 17:863–868PubMedGoogle Scholar
  11. Laurent S, Hayoz D, Trazzi S, Boutouyrie P, Waeber B, Omboni S, Brunner HR, Mancia G, Safar M (1993) Isobaric compliance of the radial artery is increased in patients with essential hypertension. J Hypertens 11:89–98PubMedCrossRefGoogle Scholar
  12. Murgo JP, Westerhof N, Giolma JP, Altobelli SA (1980) Aortic input impedance in normal man: relationship to pressure wave forms. Circulation 62:105–116PubMedGoogle Scholar
  13. Nichols WW (2005) Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms. Am J Hypertens 18:3S–10SPubMedCrossRefGoogle Scholar
  14. Nichols WW, O’Rourke MF (2005) McDonald’s blood flow in arteries: theoretical, experimental and clinical principles, 5th edn. Hodder Arnold Publishing, LondonGoogle Scholar
  15. Nichols WW, Singh BM (2002) Augmentation index as a measure of peripheral vascular disease state. Curr Opin Cardiol 17:543–551PubMedCrossRefGoogle Scholar
  16. Pascualy M, Petrie EC, Brodkin K, Peskind ER, Veith RC, Raskind MA (1999) Effects of advanced aging on plasma catecholamine responses to the cold pressor test. Neurobiol Aging 20:637–642PubMedCrossRefGoogle Scholar
  17. Pauca AL, O’Rourke MF, Kon ND (2001) Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform. Hypertension 38:932–937PubMedCrossRefGoogle Scholar
  18. Roman MJ, Devereux RB, Kizer JR, Lee ET, Galloway JM, Ali T, Umans JG, Howard BV (2007) Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the strong heart study. Hypertension 50:197–203PubMedCrossRefGoogle Scholar
  19. Schobel HP, Heusser K, Schmieder RE, Veelken R, Fischer T, Luft FC (1998) Evidence against elevated sympathetic vasoconstrictor activity in borderline hypertension. J Am Soc Nephrol 9:1581–1587PubMedGoogle Scholar
  20. Victor RG, Leimbach WN Jr, Seals DR, Wallin BG, Mark AL (1987) Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension 9:429–436PubMedGoogle Scholar
  21. Wilkinson IB, Fuchs SA, Jansen IM, Spratt JC, Murray GD, Cockcroft JR, Webb DJ (1998) Reproducibility of pulse wave velocity and augmentation index measured by pulse wave analysis. J Hypertens 16:2079–2084PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Darren P. Casey
    • 1
    • 2
    Email author
  • Randy W. Braith
    • 1
  • Gary L. Pierce
    • 1
  1. 1.Center for Exercise Science, Department of Applied Physiology and Kinesiology, College of Health and Human PerformanceUniversity of FloridaGainesvilleUSA
  2. 2.Department of AnesthesiologyMayo ClinicRochesterUSA

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