European Journal of Applied Physiology

, Volume 100, Issue 3, pp 267–274

The validity of estimating quadriceps volume from single MRI cross-sections in young men

  • Christopher I. Morse
  • Hans Degens
  • David A. Jones
Original Article

DOI: 10.1007/s00421-007-0429-4

Cite this article as:
Morse, C.I., Degens, H. & Jones, D.A. Eur J Appl Physiol (2007) 100: 267. doi:10.1007/s00421-007-0429-4

Abstract

Muscle size is often reported as a single anatomical cross-sectional area (ACSA), rather than volume measured with contiguous MRI scans. However, a single ACSA may provide an inadequate estimate of muscle mass. Therefore, we investigated whether quadriceps muscle volume can be adequately estimated from a single ACSA. In 18 adult males we derived regression equations from which estimates of volume were made. These equations were based on the direct assessment of volume using 11 transverse-plane MRI scans along the entire length of the femur (the gold standard). We estimated volume based on single scans at 40, 50 and 60% of femur length (from the distal end). All estimates of quadriceps volumes were highly correlated to the measured volume and demonstrated a low level of error. R2 = 0.84, 0.93, 0.90 (all P < 0.01), standard error of estimate (SEE) = 26.8 ± 5.2, 12.5 ± 5.4 and 9.9 ± 5.7%, for single scans taken at 40, 50 and 60% of femur length respectively. In comparison, when volume was estimated using multiple MRI scans corresponding to the maximum ACSA of each muscle the estimate was even better [R2 = 0.95 (P < 0.01) and SEE = 4.5 ± 2.7%]. Substituting ACSA from a single MRI scan at 60% of femur length into a previously determined regression equation allows for an estimation of muscle volume with a 10% error of estimate.

Keywords

Anatomical cross-sectional area Quadriceps volume Muscle mass 

Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Christopher I. Morse
    • 1
  • Hans Degens
    • 1
  • David A. Jones
    • 1
    • 2
  1. 1.Institute for Biophysical and Clinical Research into Human Movement (IRM)Manchester Metropolitan UniversityCheshireUK
  2. 2.School of Sport and Exercise SciencesThe University of BirminghamEdgbaston, BirminghamUK

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