European Journal of Applied Physiology

, Volume 99, Issue 6, pp 695–699 | Cite as

Effects of magnesium sulfate on dynamic changes of brain glucose and its metabolites during a short-term forced swimming in gerbils

  • Shiu-Min Cheng
  • Dar-Yu Yang
  • Chien-Pin Lee
  • Hung-Chuan Pan
  • Mao-Tsun Lin
  • Ssu-Hua Chen
  • Fu-Chou Cheng
Original Article


This investigation examined the acute effects of magnesium on the dynamic changes of brain glucose, lactate, pyruvate and magnesium levels in conscious gerbils during forced swimming. Gerbils were pretreated with saline (control group) and magnesium sulfate (90 mg kg−1, intraperitoneal injection) before a 15 min forced swimming period. The basal levels of glucose, pyruvate, lactate, and magnesium in brain dialysates were 338 ± 18, 21 ± 2, 450 ± 39, and 2.1 ± 0.1 μM, respectively, with no significant difference between groups. Magnesium levels were found slightly higher (but not significant) in the magnesium-treated group. However, brain glucose and pyruvate levels in the control group decreased to about 50 and 60% of the basal level (P = 0.01) after swimming, respectively. Pretreatment with magnesium sulfate immediately increased glucose levels to about 140% of the basal level, and increased pyruvate levels to about 150% of the basal level during forced swimming (P = 0.01). Both glucose and pyruvate levels returned to the basal level after 30 min of the recovery. The lactate levels of the control group increased to about 160% of the basal level (P = 0.01) during swimming, whereas pretreatment with magnesium sulfate attenuated lactate levels to 130% of the basal level (P = 0.01). Magnesium supplementation may be beneficial because it provides an additional glucose source and may also promote the recovery of energy substrates in the brain during and after forced exercise. In order to achieve optimal physical performance, further investigation as to dosage of magnesium supplementation is needed.


Lactate Pyruvate Microdialysis Swimming 



This study was supported by grants from Taichung Veterans General Hospital (TCVGH-957316C), and the National Science Council (NSC-94-2113-M-075A-001), Taiwan.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Shiu-Min Cheng
    • 1
  • Dar-Yu Yang
    • 2
  • Chien-Pin Lee
    • 3
  • Hung-Chuan Pan
    • 4
  • Mao-Tsun Lin
    • 1
    • 5
  • Ssu-Hua Chen
    • 3
  • Fu-Chou Cheng
    • 3
  1. 1.Institute of PhysiologyNational Yang-Ming UniversityTaipeiTaiwan
  2. 2.Department of NeurosurgeryChang Bing Show Chwan Memorial HospitalChanghuaTaiwan
  3. 3.Stem Cell Center, Department of Medical ResearchTaichung Veterans General HospitalTaichungTaiwan
  4. 4.Department of NeurosurgeryTaichung Veterans General HospitalTaichungTaiwan
  5. 5.Department of CardiologyChi-Mei Medical CenterTainanTaiwan

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