European Journal of Applied Physiology

, Volume 98, Issue 5, pp 516–523 | Cite as

Relationships between pulse wave velocity and heart rate variability in healthy men with a range of moderate-to-vigorous physical activity levels

  • G. M. Perkins
  • A. Owen
  • I. L. Swaine
  • J. D. Wiles
Original Article

Abstract

Pulse wave velocity (PWV) is associated with heart rate variability (HRV) in 24–39-year-old men. This study of 40–65-year-old men ranging in moderate-to-vigorous physical activity levels investigated whether (a) PWV is related to spectral HRV, (b) using normalised units for HRV influences that relationship, and (c) HRV predicts PWV when other factors, including age and blood pressure, are accounted for. Subjects were healthy men (N = 115), mean (SD) age 50.8 (7.1) years. Carotid-femoral PWV was measured using Complior. HRV was derived from a 5 min ECG for total, high-frequency, and low-frequency power (TP, HF, and LF, respectively), the LF/HF ratio, and normalised units for HF (HFnu) and LF (LFnu). Non-parametric data were natural log-transformed. PWV was 8.5 (1.4) m s−1. TP, HF, LF, LF/HF, HFnu and LFnu were 1908 (2195) m s2, 577 (1034) m s2, 457 (514) m s2, 1.5 (1.3), 46.8 (17.9), and 49.4 (19.4), respectively. PWV was inversely associated with TP (R= 0.061, = 0.008), HF (R= 0.095, = 0.001), LF (R= 0.086, = 0.002) and HFnu (R= 0.040, = 0.031), but was not associated with LF/HF (R= 0.020, p = 0.136) or LFnu (R= 0.028 = 0.076). Only age and systolic blood pressure (adjusted R= 0.306, < 0.001) predicted PWV in multivariate analysis. This study has shown that PWV was weakly associated with TP and HF. The use of normalised units only influenced the relationship between PWV and LF. Finally, relationships between PWV and HRV are mediated through age and systolic blood pressure in this population of men ranging in moderate-to-vigorous physical activity level.

Keywords

Carotid-femoral pulse wave velocity Arterial stiffness Heart rate variability Spectral power analysis Autonomic 

References

  1. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O’Brien WL, Bassett DR, Schmitz KH, Emplaincourt PO, Jacobs DR, Leon AS (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32:S498–S516PubMedCrossRefGoogle Scholar
  2. Akselrod S, Gordon D, Madwed JB, Snidman NC, Shannon DC, Cohen RJ (1985) Hemodynamic regulation: investigation by spectral analysis. Am J Physiol 249:H867–H875PubMedGoogle Scholar
  3. Appel ML, Berger RD, Saul JP, Smith JM, Cohen RJ (1989) Beat to beat variability in cardiovascular variables: noise or music? Am J Cardiol 14:1139–1148CrossRefGoogle Scholar
  4. Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, Target R, Levy BI (1995) Assessment of arterial distensibility by automatic pulse wave velocity measurement Validation and clinical application studies. Hypertension 26:485–490PubMedGoogle Scholar
  5. Boreham CA, Ferreira I, Twisk JW, Gallagher AM, Savage MJ, Murray LJ (2004) Cardiorespiratory fitness, physical activity, and arterial stiffness. The Northern Ireland Young Hearts Project. Hypertension 44:721–726PubMedCrossRefGoogle Scholar
  6. Buchfuhrer MJ, Hansen JE, Robinson TE, Sue DY, Wasserman K, Whipp BJ (1983) Optimizing the exercise protocol for cardiopulmonary assessment. J Appl Physiol 55:1558–1564PubMedGoogle Scholar
  7. Buchheit M, Simon C, Viola AU, Doutreleau S, Piquard F, Brandenberger G (2004) Heart rate variability in sportive elderly: relationship with daily physical activity. Med Sci Sports Exerc 36:601–605PubMedCrossRefGoogle Scholar
  8. CMO Annual Report (2004) At least five a week: evidence on the impact of physical activity and its relationship to health, Department of Health, London Google Scholar
  9. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG (2002) Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 106:2085–2090PubMedCrossRefGoogle Scholar
  10. DeBoer RW, Karemaker JM, Strackee J (1987) Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model. Am J Physiol 253:H680–H689PubMedGoogle Scholar
  11. Gaballa MA, Jacob CT, Raya TE, Liu J, Simon B, Goldman S (1998) Large artery remodeling during aging: biaxial passive and active stiffness. Hypertension 32:437–443PubMedGoogle Scholar
  12. Galuszka J, Opavský J, Lukl J, Stejskal P, Zapletalová J, Salinger J (2004) Short-term spectral analysis of heart rate variability during supine-standing-supine test in patients with paroxysmal atrial fibrillation. Biomedical Papers 148:63–67Google Scholar
  13. García-González MA, Vazquez-Seisdedos C, Pallas-Areny R (2000) Variations in breathing patterns increase low frequency contents in HRV spectra. Physiol Meas 21:417–423PubMedCrossRefGoogle Scholar
  14. Gregoire J, Tuck S, Yamamoto Y, Highson RL (1996) Heart rate variability at rest and exercise: influence of age, gender, and physical training. Can J Appl Physiol 21:455–470PubMedGoogle Scholar
  15. Guérin AP, London GM, Marchais SJ, Metivier F (2000) Arterial stiffening and vascular calcifications in end-stage renal disease. Neph Dial Trans 15:1014–1021CrossRefGoogle Scholar
  16. Guérin AP, Blacher J, Pannier B, Marchais SJ, Safar ME, London GM (2001) Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 103:987–992PubMedGoogle Scholar
  17. Hansen TW, Jeppesen J, Rasmussen S, Ibsen H, Torp-Pedersen C (2004) Relation between insulin and aortic stiffness: a population-based study. J Hum Hypertens 18:1–7PubMedCrossRefGoogle Scholar
  18. Hansen TW, Staessen JA, Torp-Pedersen C, Rasmussen S, Thijs L, Ibsen H, Jeppesen J (2006) Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation 113:664–670CrossRefGoogle Scholar
  19. Hayward CS (2002) Arterial pulse wave velocity and heart rate. Hypertension 40:e8–e9PubMedCrossRefGoogle Scholar
  20. Huikuri HV, Jokinen V, Syvänne M, Nieminen MS, Airaksinen KEJ, Ikäheimo MJ, Koistinenm JM, Kauma H, Kesäniemi AY, Majahalme S, Niemelä KO, Frick MH (1999) for the Lipid Coronary Angioplasty Trial (LOCAT) study Group. Heart rate variability and progression of coronary atherosclerosis. Atheroscler Thromb Vasc Biol 19:1979–1985Google Scholar
  21. Jadhav UM, Kadam NN (2005) Non-invasive assessment of arterial stiffness by pulse-wave velocity correlates with endothelial dysfunction. Indian Heart J 57:226–232PubMedGoogle Scholar
  22. Kakiyama T, Matsuda M, Koseki S (1998) Effect of physical activity on the distensibility of the aortic wall in healthy males. Angiology 49:749–757PubMedCrossRefGoogle Scholar
  23. Katzel LI, Bleeker ER, Colman EG, Rogus EM, Sorkin JD, Goldberg AP (1995) Effects of weight loss vs aerobic exercise training on risk factors for coronary disease in healthy, obese, middle-aged and older men .A randomized controlled trial. JAMA 274:1915–1921PubMedCrossRefGoogle Scholar
  24. Kimoto E, Shoji T, Shinohara K, Inaba M, Okuno Y, Miki T, Koyama H, Emoto M, Nishizawa Y (2003) Preferential stiffening of central over peripheral arteries in type 2 diabetes. Diabetes 52:448–452PubMedGoogle Scholar
  25. Kolpakov V, Polishchik R, Bannykh S, Rekhter M, Solovjev P, Romanov Y, Tararak E, Antonov A, Mironov A (1996) Atherosclerosis-prone branch regions in human aorta: microarchitecture and cell composition of intima. Atherosclerosis 122:173–189PubMedCrossRefGoogle Scholar
  26. Kuo TBJ, Lin T, Yang CCH, Li C-L, Chen C-F, Chou P (1999) Effect of aging on gender differences in neural control of heart rate. Am J Physiol 277:H2233–H2239PubMedGoogle Scholar
  27. Lantelme P, Mestre C, Lievre M, Gressard A, Milon H (2002) Heart rate: an important confounder of pulse wave velocity assessment. Hypertension. 39:1083–1087PubMedCrossRefGoogle Scholar
  28. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, Ducimetiere P, Benetos A (2001) Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37:1236–1241PubMedGoogle Scholar
  29. Lee IM, Paffenbarger RS (2000) Associations of light, moderate, and vigorous intensity physical activity with longevity. The Harvard Alumni Health Study. Am J Epidemiol 151:293–299PubMedGoogle Scholar
  30. Leicht AS, Allen GD, Hoey AJ (2003) Influence of intensive cycling training on heart rate variability during rest and exercise. Can J Appl Physiol 28:898–909PubMedGoogle Scholar
  31. Lemogoum D, Van Bortel L, Leeman M, Degaute JP, van de Borne P (2006) Ethnic differences in arterial stiffness and wave reflections after cigarette smoking. J Hypertens 24:683–689PubMedCrossRefGoogle Scholar
  32. London GM, Guerin AP, Pannier B, Marchais SJ, Stimpel M (1995) Influence of sex on arterial hemodynamics and blood pressure. Role of Body Height. Hypertension 26:514–519PubMedGoogle Scholar
  33. Malliani A, Pagani M, Lombardi F, Cerutti S (1991) Cardiovascular neural regulation explored in the frequency domain. Circulation 84:482–492PubMedGoogle Scholar
  34. Malliani A (1999) The pattern of sympathovagal balance explored in the frequency domain. News Physiol Sci 14:111–117PubMedGoogle Scholar
  35. Malliani A, Montano N (2002) Heart rate variability as a clinical tool. Ital Heart J 3:439–445PubMedGoogle Scholar
  36. Millasseau SC, Stewart AD, Patel SJ, Redwood SR, Chowienczyk PJ (2005) Evaluation of carotid-femoral pulse wave velocity: influence of timing algorithm and heart rate. Hypertension 45:222–226PubMedCrossRefGoogle Scholar
  37. Nakao M, Nomura K, Karita K, Nishikitani M, Yano E (2004) Relationship between brachial-ankle pulse wave velocity and heart rate variability in young Japanese men. Hypertens Res 27:925–931PubMedCrossRefGoogle Scholar
  38. Ohnishi H, Saitoh S, Takagi S, Ohata J, Isobe T, Kikuchi Y, Takeuchi H, Shimamoto K (2003) Pulse wave velocity as an indicator of atherosclerosis in impaired fasting glucose: the Tanno and Sobetsu study. Diabetes Care 26:437–440PubMedGoogle Scholar
  39. O’Rourke MF, Staessen JA, Vlachopoulos C, Duprez D, Plante GE (2002) Clinical applications of arterial stiffness; definitions and reference values. Am J Hypertens 15:426–444PubMedCrossRefGoogle Scholar
  40. Paffenbarger RS, Blair SN, Lee I-M, Hyde RT (1993) Measurement of physical activity to assess health effects in free-living populations. Med Sci Sports Exerc 25:60–70PubMedCrossRefGoogle Scholar
  41. Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell’Orto S, Piccaluga E (1986) Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dogs. Circ Res 59:178–193PubMedGoogle Scholar
  42. Pinna GD, Maestri MT, La Rovere MT, Gobbi E, Fanfulla F (2006) Effect of paced breathing on ventilatory and cardiovascular variability parameters during short-term investigations of autonomic function. Am J Physiol 290:H424–H433Google Scholar
  43. Pomeranz B, Macaulay RJ, Caudill MA, Kutz I, Adam D, Gordon D, Kilborn KM, Barger AC, Shannon DC, Cohen RJ, Benson M (1985) Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol 248:H151–H153PubMedGoogle Scholar
  44. Sa Cunha R, Pannier B, Benetos A, Siché J-P, London GM, Mallion JM, Safar ME (1997) Association between high heart rate and high arterial rigidity in normotensive and hypertensive subjects. J Hypertens 15:1423–1430PubMedCrossRefGoogle Scholar
  45. Schroeder EB, Chambless LE, Liao D, Prineas RJ, Evans GW, Rosamond WD, Heiss G (2005) Diabetes, glucose, insulin and heart rate variability: The Atherosclerosis Risk in Communities (ARIC) Study. Diabetes Care 28:668–674PubMedGoogle Scholar
  46. Sierksma A, Muller M, van der Schouw YT, Grobbee DE, Hendriks HF, Bots ML (2004) Alcohol consumption and arterial stiffness in men. J Hypertens 22:357–362PubMedCrossRefGoogle Scholar
  47. Sugawara J, Hayashi K, Yokoi T, Cortez-Cooper MY, DeVan AE, Anton MA, Tanaka H (2005) Brachial-ankle pulse wave velocity: an index of central arterial stiffness? J Hum Hypertens 19:401–406PubMedCrossRefGoogle Scholar
  48. Task Force of the European Society of Cardiology, the North American Society of Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation 93:1043–1065Google Scholar
  49. Tsuji H, Venditti FJ, Manders ES, Evans JC, Larson MG, Feldman CL, Levy D (1996) Determinants of heart rate variability. J Am Coll Cardiol 28:1539–1546PubMedCrossRefGoogle Scholar
  50. Vaitkevicius PV, Fleg JL, Engel JH, O’Connor FC, Wright JG, Lakatta LE, Yin FC, Lakatta EG (1993) Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation 88:1456–1462PubMedGoogle Scholar
  51. Wennerblom B, Lurje L, Tygesen H, Vahisalo R, Hjalmarson Å (2006) Patients with uncomplicated coronary artery disease have reduced heart rate variability mainly affecting vagal tone. Heart 83:290–294CrossRefGoogle Scholar
  52. Yamashina A, Tomiyama H, Takeda K, Tsuda H, Arai T, Hirose K, Koji Y, Hori S, Yamamoto Y (2002) Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 25:359–364PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • G. M. Perkins
    • 1
  • A. Owen
    • 2
  • I. L. Swaine
    • 1
  • J. D. Wiles
    • 1
  1. 1.Sport Science, Tourism and LeisureCanterbury Christ Church UniversityCanterburyUK
  2. 2.Kent and Canterbury HospitalCanterburyUK

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