European Journal of Applied Physiology

, Volume 98, Issue 3, pp 256–262 | Cite as

The effect of acute exercise on endothelial function following a high-fat meal

  • Jaume Padilla
  • Ryan A. Harris
  • Alyce D. Fly
  • Lawrence D. Rink
  • Janet P. Wallace
Original Article

Abstract

The transient impairment of endothelial function following a high-fat meal is well established. Brachial artery flow-mediated dilation (FMD) decreases between 2 and 6 h post ingestion. Whether this impairment can be reduced with acute aerobic exercise has not been investigated. The purpose of this study was to investigate if a single sustained aerobic exercise session can counteract the postprandial attenuation in brachial artery FMD associated with the ingestion of a high-fat meal. Eight apparently healthy adults (five men, three women), age 25.5 ± 0.8 years, performed three treatment conditions in a counter-balanced design: (1) low-fat meal alone (LFM), (2) high-fat meal alone (HFM), and (3) one session of aerobic exercise presented 2 h after ingesting a high-fat meal (HFM-EX). The examination of brachial artery FMD was performed at baseline and 4 h following the ingestion of the meal for each treatment condition. A 3 × 2 (treatment × time) repeated measures ANOVA exhibited a significant interaction (= 0.019). Preprandial FMDs were similar (= 0.863) among all three treatment conditions. The FMDs following the LFM (7.18 ± 1.31%) and HFM-EX (8.72 ± 0.94%) were significantly higher (= 0.001) than the FMD following the HFM (4.29 ± 1.64%). FMD was significantly elevated above preprandial values following the HFM-EX (5.61 ± 1.54 to 8.72 ± 0.94%, = 0.005) but was unchanged following the LFM (6.17 ± 0.94 to 7.18 ± 1.31%, = 0.317) and the HFM (5.73 ± 1.23 to 4.29 ± 1.64%, = 0.160). These findings suggest that a single aerobic exercise session cannot only counteract the postprandial endothelial dysfunction induced by the ingestion of a high-fat meal, but also increase brachial artery FMD in apparently healthy adults.

Keywords

Aerobic exercise High-fat diet Postprandial endothelial dysfunction Flow-mediated dilation 

Notes

Acknowledgment

This research was supported by the Clinical Exercise Physiology Laboratory and Nutrition Sciences Laboratory at Indiana University. J. Padilla is sponsored by a fellowship from the Ministerio de Educación y Cultura de España.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Jaume Padilla
    • 1
  • Ryan A. Harris
    • 1
  • Alyce D. Fly
    • 2
  • Lawrence D. Rink
    • 3
  • Janet P. Wallace
    • 1
  1. 1.Department of Kinesiology, Clinical Exercise Physiology LaboratoryIndiana UniversityBloomingtonUSA
  2. 2.Department of Applied Health Science, Nutrition Sciences LaboratoryIndiana UniversityBloomingtonUSA
  3. 3.School of MedicineIndiana UniversityBloomingtonUSA

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