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European Journal of Applied Physiology

, Volume 97, Issue 5, pp 527–534 | Cite as

Substrate utilization during prolonged exercise with ingestion of 13C-glucose in acute hypobaric hypoxia (4,300 m)

  • F. Péronnet
  • D. MassicotteEmail author
  • N. Folch
  • B. Melin
  • N. Koulmann
  • C. Jimenez
  • L. Bourdon
  • J-C. Launay
  • G. Savourey
Original Article

Abstract

Energy substrate oxidation was measured using indirect respiratory calorimetry combined with tracer technique in five healthy young male subjects, during a 80-min exercise period on ergocycle with ingestion of 140 g of 13C-labelled glucose, in normoxia and acute hypobaric hypoxia (445 mmHg or 4,300 m), at the same relative \( {\left( {77\% \dot{V}_{{{\text{O}}_{2} \max }} } \right)} \) and absolute workload (161±8 W, corresponding to 77 and 54% \( \dot{V}_{{{\text{O}}_{{\text{2}}} {\text{max}}}} \) in hypoxia and normoxia). The oxidation rate of exogenous glucose was not significantly different in the three experimental situations: 21.4±2.9, 20.2±1.2 and 17.2±0.6 g over the last 40 min of exercise at ~77 and ~54% \( \dot{V}_{{{\text{O}}_{{\text{2}}} {\text{max}}}} \) in normoxia and in hypoxia, respectively, providing 12.5±1.5, 16.8±1.1 and 14.9±1.1% of the energy yield, although ingestion of glucose during exercise resulted in a higher plasma glucose concentration in hypoxia than normoxia. The contribution of carbohydrate (CHO) oxidation to the energy yield was significantly higher in hypoxia (92.0±2.1%) than in normoxia for both a given absolute (75.3±5.2%) and relative workload (78.1±1.8%). This greater reliance on CHO oxidation in hypoxia was entirely due to the significantly larger contribution of endogenous glucose oxidation to the energy yield: 75.9±1.7% versus 66.6±3.3 and 55.2±3.7% in normoxia at the same relative and absolute workload.

Keywords

Altitude Isotope Nutrition 

Notes

Acknowledgments

This work was supported by grants from the Natural Sciences and Engineering Research Council of Canada, and from the Région Rhône-Alpes (France): Programme de recherche thématique: Adaptations aux conditions extrêmes.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • F. Péronnet
    • 1
  • D. Massicotte
    • 2
    Email author
  • N. Folch
    • 1
  • B. Melin
    • 3
  • N. Koulmann
    • 3
  • C. Jimenez
    • 3
  • L. Bourdon
    • 3
  • J-C. Launay
    • 3
  • G. Savourey
    • 3
  1. 1.Département de kinésiologieUniversité de MontréalMontrealCanada
  2. 2.Département de KinanthropologieUniversité du Québec à MontréalMontrealCanada
  3. 3.Département des Facteurs HumainsCentre de Recherches du Service de Santé des ArméesLa TroncheFrance

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