European Journal of Applied Physiology

, Volume 95, Issue 1, pp 65–73 | Cite as

Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow

  • Haruhito Takano
  • Toshihiro Morita
  • Haruko Iida
  • Ken-ichi Asada
  • Masayoshi Kato
  • Kansei Uno
  • Ken Hirose
  • Akihiro Matsumoto
  • Katsu Takenaka
  • Yasunobu Hirata
  • Fumio Eto
  • Ryozo Nagai
  • Yoshiaki Sato
  • Toshiaki Nakajima
Original Article

Abstract

We investigated the hemodynamic and hormonal responses to a short-term low-intensity resistance exercise (STLIRE) with the reduction of muscle blood flow. Eleven untrained men performed bilateral leg extension exercise under the reduction of muscle blood flow of the proximal end of both legs pressure-applied by a specially designed belt (a banding pressure of 1.3 times higher than resting systolic blood pressure, 160–180 mmHg), named as Kaatsu. The intensity of STLIRE was 20% of one repetition maximum. The subjects performed 30 repetitions, and after a 20-seconds rest, they performed three sets again until exhaustion. The superficial femoral arterial blood flow and hemodynamic parameters were measured by using the ultrasound and impedance cardiography. Serum concentrations of growth hormone (GH), vascular endothelial growth factor (VEGF), noradrenaline (NE), insulin-like growth factor (IGF)-1, ghrelin, and lactate were also measured. Under the conditions with Kaatsu, the arterial flow was reduced to about 30% of the control. STLIRE with Kaatsu significantly increased GH (0.11±0.03 to 8.6±1.1 ng/ml, P < 0.01), IGF-1 (210±40 to 236±56 ng/ml, P < 0.01), and VEGF (41±13 to 103±38 pg/ml, P < 0.05). The increase in GH was related to neither NE nor lactate, but the increase in VEGF was related to that in lactate (r = 0.57, P < 0.05). Ghrelin did not change during the exercise. The maximal heart rate (HR) and blood pressure (BP) in STLIRE with Kaatsu were higher than that without Kaatsu. Stroke volume (SV) was lower due to the decrease of the venous return by Kaatsu, but, total peripheral resistance (TPR) did not change significantly. These results suggest that STLIRE with Kaatsu significantly stimulates the exercise-induced GH, IGF, and VEGF responses with the reduction of cardiac preload during exercise, which may become a unique method for rehabilitation in patients with cardiovascular diseases.

Keywords

Resistance exercise Ischemia Growth hormone Vascular endothelial growth factor Hemodynamics Cardiac output Rehabilitation Blood flow Preload 

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Haruhito Takano
    • 1
  • Toshihiro Morita
    • 1
  • Haruko Iida
    • 1
  • Ken-ichi Asada
    • 1
  • Masayoshi Kato
    • 1
  • Kansei Uno
    • 1
  • Ken Hirose
    • 2
  • Akihiro Matsumoto
    • 1
  • Katsu Takenaka
    • 1
  • Yasunobu Hirata
    • 1
  • Fumio Eto
    • 2
  • Ryozo Nagai
    • 1
  • Yoshiaki Sato
    • 3
  • Toshiaki Nakajima
    • 1
    • 3
  1. 1.Department of Cardiovascular MedicineUniversity of TokyoBunkyo-ku, TokyoJapan
  2. 2.Department of Rehabilitation, Faculty of MedicineUniversity of TokyoBunkyo-ku, TokyoJapan
  3. 3.Department of Ischemic Circulatory PhysiologyUniversity of TokyoBunkyo-ku, TokyoJapan

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