European Journal of Applied Physiology

, Volume 93, Issue 4, pp 429–434 | Cite as

Effects of exercise training and detraining on cutaneous microvascular function in man: the regulatory role of endothelium-dependent dilation in skin vasculature

  • Jong-Shyan Wang
Original Article


This study investigated how exercise training and detraining affect the cutaneous microvascular function and the regulatory role of endothelium-dependent dilation in skin vasculature. Ten healthy sedentary subjects cycled on an ergometer at 50% of maximal oxygen uptake (O2max) for 30 min daily, 5 days a week, for 8 weeks, and then detrained for 8 weeks. Plasma nitric oxide (NO) metabolites (nitrite plus nitrate) were measured by a microplate fluorometer. The cutaneous microvascular perfusion responses to six graded levels of iontophoretically applied 1% acetylcholine (ACh) and 1% sodium nitroprusside (SNP) in the forearm skin were determined by laser Doppler. After training, (1) resting heart rate and blood pressure were reduced, whereasO2max, skin blood flow and cutaneous vascular conductance to acute exercise were enhanced; (2) plasma NO metabolite levels and ACh-induced cutaneous perfusion were increased; (3) skin vascular responses to SNP did not change significantly. However, detraining reversed these effects on cutaneous microvascular function and plasma NO metabolite levels. The results suggest that endothelium-dependent dilation in skin vasculature is enhanced by moderate exercise training and reversed to the pretraining state with detraining.


Skin blood flow Physical conditioning Nitric oxide 



This study was supported by the National Science Council of Taiwan, Republic of China (grants NSC 88-2314-B-182–080). The authors would like to thank the volunteers for their enthusiastic participation in this study.


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  1. 1.Graduate Institute of Rehabilitation Sciences and Center for Gerontological ResearchChang Gung UniversityTao-YuanTaiwan

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