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European Journal of Applied Physiology

, Volume 92, Issue 4–5, pp 462–469 | Cite as

Gender difference in the metabolic response to prolonged exercise with [13C]glucose ingestion

  • Hanèn M’Kaouar
  • François Péronnet
  • Denis MassicotteEmail author
  • Carole Lavoie
Original Article

Abstract

The metabolic response to a 120-min cycling exercise with ingestion of [13C]glucose (3 g kg−1) was compared in women in the follicular phase of the cycle [n=6; maximum rate of oxygen uptake (O2max) 44.7 (2.6) ml kg−1 min−1] and in men [n=6;O2max 54.2 (4.3) ml kg−1 min−1] working at the same relative workload (~65%O2max: 107 and 179 W in women and men, respectively). We hypothesized that the contribution of endogenous substrate oxidations (indirect respiratory calorimetry corrected for protein oxidation) to the energy yield will be similar in men and women, but that women will rely more than men on exogenous glucose oxidation. Over the exercise period, the respective contributions of protein, lipid and carbohydrate oxidation to the energy yield, were similar in men [3.7 (0.9), 21.7 (2.9) and 74.6 (3.5)%] and women [3.4 (0.8), 21.5 (2.2), 75.1 (2.5)%]. The rate of exogenous glucose oxidation was ~45% lower in women than men (0.5 and 0.6 g min−1 vs 0.7 and 0.9 g min−1, between min 40 and 80, and min 80 and 120, respectively). However, when the ~39% difference in absolute workload and energy expenditure was taken into account, the contribution of exogenous glucose oxidation to the energy yield was similar in men and women: 22.5 vs 24.2% between min 40 and 80, and 25.7 and 28.5% between min 80 and 120, respectively. These data indicate that when fed glucose, the respective contributions of the oxidation of the various substrates to the energy yield during prolonged exercise at the same %O2max are similar in men and in women in the follicular phase of the cycle.

Keywords

Gender differences Indirect respiratory calorimetry Protein oxidation Stable isotopes 

Notes

Acknowledgements

This study was supported by grants from the Natural Sciences and Engineering Research Council of Canada, and le Centre de recherche en géochimie isotopique et géodynamique UQAM–McGill (GEOTOP).

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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Hanèn M’Kaouar
    • 1
  • François Péronnet
    • 1
  • Denis Massicotte
    • 2
    Email author
  • Carole Lavoie
    • 3
  1. 1.Département de kinésiologieUniversité de MontréalMontrealCanada
  2. 2.Départements de kinanthropologieUniversité du Québec à MontréalMontrealCanada
  3. 3.Département des sciences de l’activité physiqueUniversité du Québec à Trois RivièresTrois-RivièresCanada

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