We investigated the effect of shift work on headache. Furthermore, we investigated whether the association between shift work and headache was explained by potential mediators in terms of perceived stress, poor sleep and health behaviors.
In this longitudinal study, we used questionnaire data (collected in 2007 and 2009) from civil servants and hospital employees from the PRISME study. 2952 individuals were available for the analyses of shift work and headache and 2272 individuals were available for the analyses of shift work and migraine. Headache was operationalized as the participants’ experience of “being bothered by headache during the past 4 weeks”. Migraine was operationalized as “ever being diagnosed with migraine by a medical doctor”. We used binary logistic regression to compare shift workers with permanent day workers and adjusted for socio-demographic factors. In a subsequent step, we adjusted for potential mediators.
We found higher odds of unspecific headache (OR = 1.25; 95% CI 1.02–1.54) and migraine (OR = 1.72; 95% CI 1.04–2.86) among shift workers compared with day workers. Our results suggest that the effect of shift work on headache and migraine differ between men and women. Inclusion of potential mediators in the analyses did not attenuate the associations.
Shift workers have higher risk of reporting being bothered by headache as well as reporting being diagnosed with migraine. Future research is needed to disentangle the underlying mechanisms with the aim of reducing headache related to occupational exposures.
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Conflict of interest
The authors declare that they have no conflict of interest.
The data collection was approved by The Danish National Committee on Health Research Ethics (RRS 2006–1028, 2747-06) and the Danish Data Protection Agency (2009-41-3215). The study was in accordance with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
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Appel, A.M., Török, E., Jensen, M.A. et al. The longitudinal association between shift work and headache: results from the Danish PRISME cohort. Int Arch Occup Environ Health (2020). https://doi.org/10.1007/s00420-019-01512-6
- Night work
- Evening work
- Rotating shift