Work-related stress and incident asthma and rhinitis: results from the SOLAR study
- 38 Downloads
This study analyzes the association of work-related stress with incident asthma and rhinitis in young adults with a special focus on gender-specific differences.
Incident asthma, wheezing and rhinitis were measured in a cohort of 2051 young German adults (aged 16–18 years at baseline) recruited by the prospective population-based SOLAR study (Study of Occupational Allergy Risks). Work-related stress was measured by the Trier Inventory for the Assessment of Chronic Stress (TICS). Two TICS scales, work overload and work discontent, were analysed. Logistic regression was conducted to calculate odds ratios (OR) and 95% confidence intervals (CI).
In females, the odds for incident asthma were found to be 17% higher for each increase of the work discontent score by one point (OR 1.17, 95% CI 1.04–1.31). In males, no association was statistically significant. Incident rhinitis showed no association with any exposure variable.
This study shows a link between work-related stress and incident asthma which seems to be confined to women. This study adds evidence about the association of work-related stress and asthma in young adults and can contribute to prevention for that particular age group.
KeywordsIncident asthma Incident rhinitis Work-related stress Young adults
The authors thank all participants and the study team for their contribution. Ronald Herrera (Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich) and Carla Sabariego (Department of Medical Informatics, Biometry and Epidemiology, LMU Munich) are gratefully acknowledged for their comments on the manuscript.
The ISAAC Phase Two study in Dresden and Munich was funded by the German Ministry of Education and Research (01 EE 9411-3). The SOLAR I study was supported by the German Ministry for Economy and Labour. The SOLAR II study was funded by the German Federal Institute for Occupational Safety and Health and the German Ministry of Labour and Social Affairs.
Compliance with ethical standards
Conflict of interest
CV, DN, DW, FF, GW, JGen, JGer, KR, and TW: none. EvM: grants from German Ministry of Education and Research, during the conduct of the study; personal fees from Massachusetts Medical Society, personal fees from American Academy of Allergy, Asthma and Immunology, personal fees from Novartis Pharma SAS, personal fees from PharmaVentures, personal fees from OM Pharma, personal fees from Decision Resources, personal fees from The Chinese University of Hong Kong, personal fees from University of Copenhagen, personal fees from HAL Allergie GmbH, personal fees from Ökosoziales Forum Oberösterreich, personal fees from Mundipharma, personal fees from American Thoracic Society, personal fees from AbbVie Deutschland GmbH & Co. KG, personal fees from University of Tampere, personal fees from European Commission, personal fees from University of Turku, personal fees from University Helsinki, personal fees from Peptinnovate, outside the submitted work. WS: personal fees from Hogrefe Publishers, outside the submitted work.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Ethical Committee of the Medical Faculty of the University of Dresden (Dresden, Germany), the Ethical Committee of the Bavarian Chamber of Physicians (Munich, Germany) and by the Ethical Committee of Ulm University (Ulm, Germany).
Informed consent was obtained from all study participants, or their guardians if the participants were younger than 18 years.
- Cazzoletti L, Marcon A, Janson C, Corsico A, Jarvis D, Pin I, Accordini S, Almar E, Bugiani M, Carolei A, Cerveri I, Duran-Tauleria E, Gislason D, Gulsvik A, Jogi R, Marinoni A, Martinez-Moratalla J, Vermeire P, Marco R de (2007) Asthma control in Europe: a real-world evaluation based on an international population-based study. J Allergy Clin Immunol 120(6):1360–1367CrossRefGoogle Scholar
- Eurofound (2016) Sixth European working conditions survey—overview report. Publications Office of the European Union, LuxembourgGoogle Scholar
- Health and Safety Executive (2016) Work related stress, anxiety and depression statistics in Great Britain 2016. http://www.hse.gov.uk/statistics/. Accessed 19 Oct 2017
- Heikkilä K, Madsen IEH, Nyberg ST, Fransson EI, Westerlund H, Westerholm PJM, Virtanen M, Vahtera J, Vaananen A, Theorell T, Suominen SB, Shipley MJ, Salo P, Rugulies R, Pentti J, Pejtersen JH, Oksanen T, Nordin M, Nielsen ML, Kouvonen A, Koskinen A, Koskenvuo M, Knutsson A, Ferrie JE, Dragano N, Burr H, Borritz M, Bjorner JB, Alfredsson L, Batty GD, Singh-Manoux A, Kivimaki M (2014) Job strain and the risk of severe asthma exacerbations: a meta-analysis of individual-participant data from 100 000 European men and women. Allergy 69(6):775–783CrossRefGoogle Scholar
- Honaker J, King G, Blackwell M (2011) Amelia II: a program for missing data. J Stat Softw 45(1):1–47Google Scholar
- King G, Honaker J, Joseph A, Scheve K (2001) Analyzing incomplete political science data: an alternative algorithm for multiple imputation. Am Polit Sci Rev 95(1):49–69Google Scholar
- Le Moual N, Carsin A-E, Siroux V, Radon K, Norback D, Toren K, Olivieri M, Urrutia I, Cazzoletti L, Jacquemin B, Benke G, Kromhout H, Mirabelli MC, Mehta AJ, Schlunssen V, Sigsgaard T, Blanc PD, Kogevinas M, Anto JM, Zock J-P (2014) Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II. Eur Respir J 43(2):374–386CrossRefGoogle Scholar
- Marco R de, Marcon A, Jarvis D, Accordini S, Almar E, Bugiani M, Carolei A, Cazzoletti L, Corsico A, Gislason D, Gulsvik A, Jogi R, Marinoni A, Martinez-Moratalla J, Pin I, Janson C (2006) Prognostic factors of asthma severity: a 9-year international prospective cohort study. J Allergy Clin Immunol 117(6):1249–1256CrossRefGoogle Scholar
- Mensink GBM, Schienkiewitz A, Haftenberger M, Lampert T, Ziese T, Scheidt-Nave C (2013) Übergewicht und Adipositas in Deutschland: Ergebnisse der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1) (Overweight and obesity in Germany: results of the German Health Interview and Examination Survey for Adults (DEGS1)). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56(5–6):786–794CrossRefGoogle Scholar
- R Core Team (2017) R: a language and environment for statistical computing, Vienna, Austria. https://www.R-project.org/. Accessed 17 Jan 2018
- Radon K, Nowak D, Vogelberg C, Rueff F (2016) Career advice for young allergy patients. Dtsch Arztebl Int 113(31–32):519–524Google Scholar
- Sansone RA, Sansone LA (2011) Allergic rhinitis: relationships with anxiety and mood syndromes. Innov Clin Neurosci 8(7):12–17Google Scholar
- Schulz P, Schlotz W, Becker P (2004) TICS: Trierer Inventar zum chronischen Stress. Manual für Version 3. Hogrefe, GöttingenGoogle Scholar