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Exposure to field vs. storage wheat dust: different consequences on respiratory symptoms and immune response among grain workers

  • Coralie Barrera
  • Pascal Wild
  • Victor Dorribo
  • Dessislava Savova-Bianchi
  • Audrey Laboissière
  • Jacques A. Pralong
  • Brigitta Danuser
  • Peggy Krief
  • Laurence Millon
  • Gabriel Reboux
  • Hélène Niculita-Hirzel
Original Article
  • 122 Downloads

Abstract

Purpose

The aim of this study was to understand the differential acute effects of two distinct wheat-related dusts, such as field or stored wheat dust handling, on workers’ health and how those effects evolved at 6 month intervals.

Methods

Exposure, work-related symptoms, changes in lung function, and blood samples of 81 workers handling wheat and 61 controls were collected during the high exposure season and 6 months after. Specific IgG, IgE, and precipitins against 12 fungi isolated from wheat dust were titrated by enzyme-linked immunosorbent assay, dissociation-enhanced lanthanide fluorescence immunoassay, and electrosyneresis. The level of fungi was determined in the workers’ environment. Levels of exhaled fraction of nitrogen monoxide (FENO) and total IgE were obtained. Exposure response associations were investigated by mixed logistic and linear regression models.

Results

The recent exposure to field wheat dust was associated with a higher prevalence for five of six self-reported airway symptoms and with a lower FENO than those in the control population. Exposure to stored wheat dust was only associated with cough. No acute impact of exposure on respiratory function was observed. Exposure to field wheat dust led to workers’ sensitization against the three field fungi Aureobasidum, Cryptococcus, and Phoma, although exposure to storage wheat dust was associated with tolerance. The level of Ig remained stable 6 months after exposure.

Conclusion

The clinical picture of workers exposed to field or storage wheat dust differed. The systematic characterization of the aerosol microbial profile may help to understand the reasons for those differences.

Keywords

Grain workers Cattle raisers Respiratory symptoms Occupational wheat dust exposure Fungi-specific immunoglobulins 

Notes

Acknowledgements

We thank Dr. C. Lazor-Blanchet and M. Coté for their support recruiting the controls, M. Porchet and D. Spinedi for helping with data collection, Y. Randin for data management supportand BioMed Proofreading® LLC experts to correct the English.

Funding

The study was funded by the ANSES (Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail, France) Grant 2011/1/087 to HNH and by a SUVA (Caisse nationale suisse d’assurance en cas d’accidents) grant to PK and BD. The funding organs played no role in the collection of data, formulation of study hypothesis analyses, or interpretation of findings.

Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

420_2018_1322_MOESM1_ESM.docx (24 kb)
Supplementary material 1 (DOCX 25 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Coralie Barrera
    • 1
    • 2
  • Pascal Wild
    • 3
    • 4
  • Victor Dorribo
    • 5
  • Dessislava Savova-Bianchi
    • 3
  • Audrey Laboissière
    • 1
    • 2
  • Jacques A. Pralong
    • 5
  • Brigitta Danuser
    • 5
  • Peggy Krief
    • 5
  • Laurence Millon
    • 1
    • 2
  • Gabriel Reboux
    • 1
    • 2
  • Hélène Niculita-Hirzel
    • 3
  1. 1.UMR6249 Chrono-EnvironnementUniversity of Franche-ComtéBesançonFrance
  2. 2.Parasitology-Mycology DepartmentUniversity Hospital of BesançonBesançonFrance
  3. 3.Service of Occupational Hygiene, Institute for Work and HealthUniversity of Lausanne and GenevaEpalinges-LausanneSwitzerland
  4. 4.Scientific ManagementINRSNancyFrance
  5. 5.Service of Occupational Medicine, Institute for Work and HealthUniversity of Lausanne and GenevaEpalinges-LausanneSwitzerland

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