Traffic-related air pollution is associated with cardio-metabolic biomarkers in general residents
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The study was conducted to explore the mechanisms linking traffic-related air pollution and cardio-metabolic risk.
The participants included 371 men and women aged from 45 to 75 in an urban residential area in Shanghai, China. The participants were divided into four categories (≤50, 51–100, 101–200 and >200 m) according to the residential distance to major road. Additionally, the personal fine particulate matter (PM2.5) was measured from 8:00 am to 6:00 pm to assess the PM2.5 exposure in general residents. Then, the continuous subclinical measurements and biological effects related to cardio-metabolic disorders were detected. The generalized linear regression analysis was applied for estimating the adjusted hazards ratio for cardio-metabolic disorders relative to traffic-related air pollution.
The average personal PM2.5 is 111.1 μg/m3 in the participants living within 50 m to major road, which is significantly higher than the personal PM2.5 (68.2 μg/m3) in the participants living more than 200 m away from the major road. The participants living within 50 m to major road compared with those living more than 200 m away have 1.15 times higher of heart rate (HR), 1.95 times higher of fasting insulin, 1.30 times higher of homeostasis model assessment of insulin resistance (HOMA-IR), 1.56 times higher of low-density lipoprotein cholesterol (LDL-C), 8.39 times higher of interleukin 6 (IL-6), 4.30 times higher of augmentation index (AI), 1.60 times higher of systolic blood pressure (SBP) and 1.91 times higher of diastolic blood pressure (DBP). Contrary to the increase in above biological effects, there were 1.06 times lower of low frequency (LF), 1.05 times lower of high frequency (HF), 2.54 times lower of IL-10, 4.61 times lower of nitric oxide (NO), 1.19 times lower of superoxide dismutase (SOD) and 1.85 times lower of total antioxidant capacity (T-AOC). There was no clear exposure–response relationship can be observed in the fasting glucose, LF/HF, cholesterol and high-density lipoprotein (HDL).
Long-term exposure to traffic-related air pollution may contribute to the development or exacerbation of cardio-metabolic disorders. The mechanisms linking air pollution and cardio-metabolic disorders may be associated with the increased systemic inflammation and oxidative stress, reduced insulin sensitivity and elevated arterial stiffness and blood pressure.
KeywordsTraffic-related air pollution Fine particulate matter Cardio-metabolic disorders
This work was supported by the grants from the National Natural Science Foundation of China (No. 91543119, 81001229).
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest.
- Brook RD, Rajagopalan S, Pope CR, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SJ, Whitsel L, Kaufman JD (2010) Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 121:2331–2378CrossRefGoogle Scholar
- Ghosh R, Lurmann F, Perez L, Penfold B, Brandt S, Wilson J, Milet M, Kunzli N, McConnell R (2016) Near-roadway air pollution and coronary heart disease: burden of disease and potential impact of a greenhouse gas reduction strategy in Southern California. Environ Health Perspect 124:193–200Google Scholar
- Hampel R, Peters A, Beelen R, Brunekreef B, Cyrys J, de Faire U, de Hoogh K, Fuks K, Hoffmann B, Huls A, Imboden M, Jedynska A, Kooter I, Koenig W, Kunzli N, Leander K, Magnusson P, Mannisto S, Penell J, Pershagen G, Phuleria H, Probst-Hensch N, Pundt N, Schaffner E, Schikowski T, Sugiri D, Tiittanen P, Tsai MY, Wang M, Wolf K, Lanki T (2015) Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts. Environ Int 82:76–84CrossRefGoogle Scholar
- Kingsley SL, Eliot MN, Whitsel EA, Wang Y, Coull BA, Hou L, Margolis HG, Margolis KL, Mu L, Wu WC, Johnson KC, Allison MA, Manson JE, Eaton CB, Wellenius GA (2015) Residential proximity to major roadways and incident hypertension in post-menopausal women. Environ Res 142:522–528CrossRefGoogle Scholar
- Latalova K, Prasko J, Diveky T, Grambal A, Kamaradova D, Velartova H, Salinger J, Opavsky J (2010) Autonomic nervous system in euthymic patients with bipolar affective disorder. Neuro Endocrinol Lett 31:829–836Google Scholar
- Sun Q, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, Cai Y, Ostrowski MC, Lu B, Parthasarathy S, Brook RD, Moffatt-Bruce SD, Chen LC, Rajagopalan S (2009) Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119:538–546CrossRefGoogle Scholar
- Sun Z, Mukherjee B, Brook RD, Gatts GA, Yang F, Sun Q, Brook JR, Fan Z, Rajagopalan S (2013) Air-pollution and cardiometabolic diseases (AIRCMD): a prospective study investigating the impact of air pollution exposure and propensity for type II diabetes. Sci Total Environ 448:72–78CrossRefGoogle Scholar
- Thiering E, Cyrys J, Kratzsch J, Meisinger C, Hoffmann B, Berdel D, von Berg A, Koletzko S, Bauer CP, Heinrich J (2013) Long-term exposure to traffic-related air pollution and insulin resistance in children: results from the GINIplus and LISAplus birth cohorts. Diabetologia 56:1696–1704CrossRefGoogle Scholar
- Weinmayr G, Hennig F, Fuks K, Nonnemacher M, Jakobs H, Mohlenkamp S, Erbel R, Jockel KH, Hoffmann B, Moebus S (2015) Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution. Environ Health 14:53CrossRefGoogle Scholar
- Xie Y, Bo L, Jiang S, Tian Z, Kan H, Li Y, Song W, Zhao J (2016) Individual PM exposure is associated with the impairment of cardiac autonomic modulation in general residents. Environ Sci Pollut Res Int. doi: 10.1007/s11356-015-5933-1
- Xu Z, Xu X, Zhong M, Hotchkiss IP, Lewandowski RP, Wagner JG, Bramble LA, Yang Y, Wang A, Harkema JR, Lippmann M, Rajagopalan S, Chen LC, Sun Q (2011b) Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues. Part Fibre Toxicol 8:20CrossRefGoogle Scholar
- Ying Z, Xu X, Bai Y, Zhong J, Chen M, Liang Y, Zhao J, Liu D, Morishita M, Sun Q, Spino C, Brook RD, Harkema JR, Rajagopalan S (2014) Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: a role for hypothalamic inflammation. Environ Health Perspect 122:79–86Google Scholar