Effects of electromagnetic fields exposure on plasma hormonal and inflammatory pathway biomarkers in male workers of a power plant
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The potential health risks of electromagnetic fields (EMFs) have currently raised considerable public concerns. The aim of this study was to evaluate the effects of EMF exposure on levels of plasma hormonal and inflammatory pathway biomarkers in male workers of an electric power plant.
Seventy-seven male workers with high occupational EMF exposure and 77 male controls with low exposure, matched by age, were selected from a cross-sectional study. Moreover, high EMF exposure group was with walkie-talkies usage and exposed to power frequency EMF at the work places for a longer duration than control group. A questionnaire was applied to obtain relevant information, including sociodemographic characteristics, lifestyle factors, and EMF exposures. Plasma levels of testosterone, estradiol, melatonin, NF-κB, heat–shock protein (HSP) 70, HSP27, and TET1 were determined by an enzyme-linked immunosorbent assay.
EMF exposure group had statistically significantly lower levels of testosterone (β = −0.3 nmol/L, P = 0.015), testosterone/estradiol (T/E2) ratio (β = −15.6, P = 0.037), and NF-κB (β = −20.8 ng/L, P = 0.045) than control group. Moreover, joint effects between occupational EMF exposure and employment duration, mobile phone fees, years of mobile phone usage, and electric fees on levels of testosterone and T/E2 ratio were observed. Nevertheless, no statistically significant associations of EMF exposures with plasma estradiol, melatonin, HSP70, HSP27, and TET1 were found.
The findings showed that chronic exposure to EMF could decrease male plasma testosterone and T/E2 ratio, and it might possibly affect reproductive functions in males. No significant associations of EMF exposure with inflammatory pathway biomarkers were found.
KeywordsElectromagnetic fields Testosterone/estradiol Melatonin Heat–shock protein NF-κB TET1
The authors would like to thank the staff of Ningbo Medical Treatment Center Lihuili Hospital for their continuous support and assistance to collect blood specimen. We are particularly grateful for the supports and contributions of all participants and their family. This study was supported by the National Basic Research Program of China (973 Program) (Grant No.: 2011CB503706), the National Natural Science Foundation of China (Grant No.: 81172624), and Natural Science Foundation of Zhejiang Province, China (Grant No.: LY14H260003).
Conflict of interest
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