Accidental exposure to polychlorinated biphenyls (PCB) in waste cargo after heavy seas. Global waste transport as a source of PCB exposure
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After cargo with PCB-containing transformer oil waste was damaged in heavy seas, the vessel crew exposed to PCB developed itching and acne-form eruption of the skin. The objective of our study was to analyse this work-related incident and its effects on health.
Air and wipe test samples were taken in the ship for analysis of PCB (28/52/101/138/153/180); clinical investigations of all seafarers (n = 6) included lung function, chest X-ray, clinical chemistry and biomonitoring (plasma PCBs, chlorophenols in urine) measured after a latency of 7 weeks. The biomonitoring data were adjusted according to age-related reference values and validated against controls (n = 96).
Biomonitoring showed elevated PCB-28-/52/-102/-138 congeners (mean 1.16/0.91/136, ∑PCB: 5.82 μg/l), which correlates with the dust samples from the cargo hold (∑PCB. 9,440 mg/m2) and with 6.1 and 5.0 μg/m3 in stern and bow cargo air samples. IgE elevation in two seafarers and substantial blood sedimentation rate increase with anaemia or pulmonary emphysema were unlikely to be caused by PCB exposure. Although two members showed slightly elevated airway resistance values, other lung function parameters were normal and reactive airways dysfunction syndrome due to PCBs could be excluded. Elevated chlorophenols in urine could contribute to the manifestation of chloracne.
PCB-52/-101/-138 found in plasma and in air samples confirm exposure to PCB. Acne-form skin eruptions were from occupational exposure to polychlorinated biphenyls in the spilt transformer oil. There were no other abnormal findings in medical and clinical examinations that could be attributed to PCBs. This does not exclude possible long-term effects.
KeywordsPolychlorinated biphenyls (PCB) Seafarers Chlorophenols Accidental exposure Clinical and laboratory diagnosis RADS (reactive airways dysfunction syndrome)
- Chest X-ray
- FEV1/FVC %
Forced expiratory volume in 1 s/inspiratory vital capacity
We acknowledge the laboratories Fresenius, Frankfurt/Main, and Dr. Wiertz Eggert and Dr. Jörissen, Hamburg, who did the PCB monitoring in ambient air and in the wipe test samples; ZfAM colleagues for help in supporting the collection of the clinical data; Dr. Wurm for his X-ray investigations; Mrs. Johannsen for lung function testing; Mrs. Koops for flow cytometry; Mrs. Tieu for analysis of the PCBs and chlorophenols; and Dr. Kevan Willey for critical appraisal of the manuscript. The study was funded by the State Ministry for Health and Consumer Protection (XB, RW) and is a part of the WHO GPA (global plan of action) project: New chemical health risk hazards in transportation and warehousing of marine cargo because of globalisation (LTB).
Conflict of interest
The authors declare that they have no conflicts of interest.
- Adams ET, Auerbach S, Blackshear PE, Bradley A, Gruebbel MM, Little PB, Malarkey D, Maronpot R, McKay JS, Miller RA, Moore RR, Morrison JP, Nyska A, Ramot Y, Rao D, Suttie A, Wells MY, Willson GA, Elmore SA (2011) Proceedings of the 2010 national toxicology program satellite symposium. Toxicol Pathol 39(1):240–266CrossRefGoogle Scholar
- Altenkirch H, Stoltenburg G, Haller D, Hopmann D, Walter G (1996) Clinical data on three cases of occupationally induced PCB-intoxication. Neurotoxicology 17(3–4):639–643Google Scholar
- Crinnion WJ (2011) Polychlorinated biphenyls: persistent pollutants with immunological, neurological, and endocrinological consequences. Altern Med Rev 16(1):5–13Google Scholar
- Deutch B, Hansen JC (1999) High blood levels of persistent organic pollutants are statistically correlated with smoking. Int J Circumpolar Health 58(3):214–219Google Scholar
- DFG (2012) Analytical methods from the working group on analytical chemistry, AibM, DFG German Research Council (MAK commission) publications. http://onlinelibrarywileycom/book/101002/3527600418/topics
- Hany J, Lilienthal H, Sarasin A, Roth-Harer A, Fastabend A, Dunemann L, Lichtensteiger W, Winneke G (1999) Developmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: effects on organ weights, aromatase activity, sex hormone levels, and sweet preference behaviour. Toxicol Appl Pharmacol 158(3):231–243CrossRefGoogle Scholar
- Hartwig A (2012) The MAK-collection for occupational health and safety. Villey-VCH http://onlinelibrarywileycom/book/101002/3527600418/topics
- Hirota Y, Hirohata T, Kataoka K, Shinohara S, Tokiwa H (1993) Laboratory findings in the medical examination of chronic “Yusho” (PCB poisoning) patients with special reference to blood PCB and serum triglyceride. Fukuoka Igaku Zasshi 84:287–293Google Scholar
- Lazaro R, Herrera A, Conchello MP, Arino AA, Bayarri S, Yague C, Peiro JM (1999) Levels of selected polychlorinated biphenyl congeners in total diet samples from Aragon, Spain. J Food Prot 62(9):1054–1058Google Scholar
- Lemesh RA (1992) Polychlorinated biphenyls: an overview of metabolic toxicologic and health consequences. Vet Hum Toxicol 34(3):256–260Google Scholar
- Maroni M, Colombi A, Arbosti G, Cantoni S, Foa V (1981) Occupational exposure to polychlorinated biphenyls in electrical workers. II. Health effects. Br J Ind Med 38(1):55–60Google Scholar
- Nakanishi Y, Nomoto Y, Matsuki A, Kunitake R, Hara N (1995) Effect of polychlorinated biphenyls and polychlorinated dibenzofurans on leukocyte in peripheral blood and bronchoalveolar lavage fluid. Fukuoka Igaku Zasshi 86(5):261–266Google Scholar
- NIOSH C (2006) Exposure to Polychlorinated Biphenyls and the Risk of Disease. http://wwwcdcgov/niosh/pgms/worknotify/PCB2html
- Prince MM, Ruder AM, Hein MJ, Waters MA, Whelan EA, Nilsen N, Ward EM, Schnorr TM, Laber PA, Davis-King KE (2006) Mortality and exposure response among 14,458 electrical capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs). Environ Health Perspect 114(10):1508–1514CrossRefGoogle Scholar
- Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver B, Enright PL, Hankinson JL, Ip MS, Zheng J, Stocks J (2012) Multi-ethnic reference values for spirometry for the 3–95 year age range: the global lung function 2012 equations. Eur Respir J. doi: 10.1183/09031936.00080312
- Rallis GN, Sakkas VA, Boumba VA, Vougiouklakis T, Albanis TA (2012) Determination of organochlorine pesticides and polychlorinated biphenyls in post-mortem human lung by matrix solid-phase dispersion with the aid of response surface methodology and desirability function. J Chromatogr A 1227:1–9CrossRefGoogle Scholar
- Recio-Vega R, Mendez-Henandez A, Gabriel AP, Jacobo-Avila A, Portales-Castanedo A, Hernandez-Gonzalez S, Gallegos-Arreola MP, Ocampo-Gomez G (2012) Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer. J Appl Toxicol. doi: 10.1002/jat.2763]
- Smith AB, Schloemer J, Lowry LK, Smallwood AW, Ligo RN, Tanaka S, Stringer W, Jones M, Hervin R, Glueck CJ (1982) Metabolic and health consequences of occupational exposure to polychlorinated biphenyls. Br J Ind Med 39(4):361–369Google Scholar
- Tokunaga S, Hirota Y, Kataoka K (1999) Association between the results of blood test and blood PCB level of chronic Yusho patients twenty five years after the outbreak. Fukuoka Igaku Zasshi 90(5):157–161Google Scholar
- Tsuji H, Hirahashi T, Ogata H, Fujishima M (1999) Serum immunoglobulin concentrations and autoantibodies in patients with Yusho. Fukuoka Igaku Zasshi 90(5):147–149Google Scholar
- UBA (2007) Health evaluation of dioxin-like polychlorinated bisphenols in indoor air. German Joint Working Group on Indoor Guidelines of the Federal Environment Agency, Department of Health; http://wwwumweltbundesamtde/gesundheit/innenraumhygiene/ dioxinaehnliche_polychlorierte_biphenylepdf
- UBA (2012) Referenzvalues for organochlride substances, polychlorinated bisphenyls, chlorophenols (UBA, German Environmental Protection Ageny) http://wwwubade/gesundheit/publikationen/indexhtml/khb
- G-Equas. External quality assessment scheme and certification for occupational-medical and environmental-medical toxicological analyses in biological materials. www.g-equas.de/