Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population
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Previous studies reported that exposure to dioxins was associated with an increased risk of various diseases in general populations.
The aim of this study was to examine the association between levels of dioxins in blood and allergic and other diseases.
We conducted a cross-sectional study on 1,063 men and 1,201 women (aged 15–76 years), who were living throughout Japan and not occupationally exposed to dioxins, during 2002–2010. In fasting blood samples, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) were analyzed by isotope dilution high-resolution gas chromatography/mass spectrometry. We obtained information on life style and self-reported history of diseases using a questionnaire. Blood pressure, blood levels of hemoglobin A1c, and serum lipids were also measured. Multiple logistic regression models were used to analyze the association between dioxin levels in blood and various diseases.
Toxic equivalents of PCDDs/PCDFs and total dioxins showed significant inverse dose–response relationships with atopic dermatitis, after adjustments for potential confounders. The highest quartile for total dioxins had an adjusted odds ratio of 0.26 (95 % confidence interval 0.08–0.70) compared to the reference group (first quartile). The odds ratios for hypertension, diabetes mellitus, hyperlipidemia, gout in men, and gynecologic diseases in women significantly increased with increasing toxic equivalents of PCDDs/PCDFs, DL-PCBs, and total dioxins in blood.
The present findings suggest that background exposure to dioxins was associated with reduced risk of atopic dermatitis. The results also support the idea that low-level exposure to dioxins is associated with an increased risk of diabetes, hypertension, and hyperlipidemia.
KeywordsAllergic diseases Atopic dermatitis DL-PCBs PCDDs PCDFs Gout
We are grateful to Drs. T. Kitamado, S. Morishita, and N. Tsukamoto of the Ministry of the Environment and M. Hijiya and Y. Chisaki of Idea Consultants, Inc., for their cooperation and encouragement during the study. We also thank all members of the committee of the “Study on the Accumulation of Dioxins in Humans”, Drs. I. Uchiyama (Graduate School of Engineering, Kyoto University), F. Kayama (Jichi Medical School), H. Saito (Nagasaki University), T. Suzuki (The University of Tokyo, deceased), N. Suzuki (National Institute for Environment Studies), T. Sobue (National Cancer Center Research Institute), C. Tohyama (The University of Tokyo), S. Tominaga (Aichi Health Promotion Foundation), H. Miyata (Faculty of Pharmaceutical Science, Setsunan University), M. Morita (National Institute for Environment Studies/Ehime University), and S. Watanabe (National Institute of Health and Nutrition). This study was performed under the supervision of the Ministry of the Environment of Japan. However, the views expressed in the present paper do not necessarily reflect the positions or policies of the ministry.
Conflict of interest
The authors declare that they have no conflict of interest.
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